Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules — The SPUtNIk study

Research output: Contribution to journalArticle

  • External authors:
  • N. R. Qureshi
  • R. C. Rintoul
  • K. A. Miles
  • S. George
  • S. Harris
  • J. Madden
  • K. Cozens
  • L. A. Little
  • K. Eichhorst
  • J. Jones
  • P. Moate
  • C. McClement
  • L. Pike
  • D. Sinclair
  • W. L. Wong
  • J. Shekhdar
  • R. Eaton
  • A. Shah
  • L. Brindle
  • C. Peebles
  • A. Banerjee
  • S. Dizdarevic
  • S. Han
  • F. W. Poon
  • A. M. Groves
  • L. Kurban
  • A. J. Frew
  • M. E. Callister
  • F. V. Gleeson
  • K. Karunasaagarar
  • O. Kankam
  • F. J. Gilbert


Introduction: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrastenhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently. Methods and analysis: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and costeffectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) (18FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for18FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs. Ethics and dissemination: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.

Bibliographical metadata

Original languageEnglish
Article numbere000156
JournalBMJ Open Respiratory Research
Issue number1
Publication statusPublished - 14 Oct 2016