Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic SyndromeCitation formats

  • External authors:
  • Kaivan Khavandi
  • Reza Aghamohammadzadeh
  • Matthew Luckie
  • Jack Brownrigg
  • Uazman Alam
  • Rajdeep Khattar
  • Rayaz A Malik

Standard

Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome. / Khavandi, Kaivan; Aghamohammadzadeh, Reza; Luckie, Matthew; Brownrigg, Jack; Alam, Uazman; Khattar, Rajdeep; Malik, Rayaz A; Heagerty, Anthony M; Greenstein, Adam S.

In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 6, No. 4, e004603, 11.04.2017.

Research output: Contribution to journalArticle

Harvard

Khavandi, K, Aghamohammadzadeh, R, Luckie, M, Brownrigg, J, Alam, U, Khattar, R, Malik, RA, Heagerty, AM & Greenstein, AS 2017, 'Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome' American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, vol. 6, no. 4, e004603. https://doi.org/10.1161/JAHA.116.004603

APA

Khavandi, K., Aghamohammadzadeh, R., Luckie, M., Brownrigg, J., Alam, U., Khattar, R., ... Greenstein, A. S. (2017). Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, 6(4), [e004603]. https://doi.org/10.1161/JAHA.116.004603

Vancouver

Khavandi K, Aghamohammadzadeh R, Luckie M, Brownrigg J, Alam U, Khattar R et al. Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2017 Apr 11;6(4). e004603. https://doi.org/10.1161/JAHA.116.004603

Author

Khavandi, Kaivan ; Aghamohammadzadeh, Reza ; Luckie, Matthew ; Brownrigg, Jack ; Alam, Uazman ; Khattar, Rajdeep ; Malik, Rayaz A ; Heagerty, Anthony M ; Greenstein, Adam S. / Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome. In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2017 ; Vol. 6, No. 4.

Bibtex

@article{4ae7de443f6347bc9d492bdb203a8f25,
title = "Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome",
abstract = "BACKGROUND: Small artery pathophysiology is frequently invoked as a cause of obesity-related diastolic heart failure. However, evidence to support this hypothesis is scant, particularly in humans.METHODS AND RESULTS: To address this, we studied human small artery structure and function in obesity and looked for correlations between vascular parameters and diastolic function. Seventeen obese patients with metabolic syndrome and 5 control participants underwent echocardiography and subcutaneous gluteal fat biopsy. Small arteries were isolated from the biopsy and pressure myography was used to study endothelial function and wall structure. In comparison with the control group, small arteries from obese participants exhibited significant endothelial dysfunction, assessed as the vasodilatory response to acetylcholine and also pathological growth of the wall. For the obese participants, multiple regression analysis revealed an association between left atrial volume and both the small artery wall thickness (β=0.718, P=0.02) and wall-to-lumen ratio (β=0.605, P=0.02). Furthermore, the E:E' ratio was associated with wall-to-lumen ratio (β=0.596, P=0.02) and inversely associated with interleukin-6 (β=-0.868, P=0.03). By contrast, endothelial function did not correlate with any of the echocardiographic parameters studied.CONCLUSIONS: Although the small arteries studied were not cardiac in origin, our results support a role for small artery remodeling in the development of diastolic dysfunction in humans. Further direct examination of the structure and function of the myocardial resistance vasculature is now warranted, to elucidate the temporal association between metabolic risk factors, small artery injury, and diastolic impairment.",
keywords = "diastolic dysfunction, endothelial dysfunction, heart failure, obesity, vascular remodeling",
author = "Kaivan Khavandi and Reza Aghamohammadzadeh and Matthew Luckie and Jack Brownrigg and Uazman Alam and Rajdeep Khattar and Malik, {Rayaz A} and Heagerty, {Anthony M} and Greenstein, {Adam S}",
note = "{\circledC} 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",
year = "2017",
month = "4",
day = "11",
doi = "10.1161/JAHA.116.004603",
language = "English",
volume = "6",
journal = "American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease",
issn = "2047-9980",
publisher = "John Wiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome

AU - Khavandi, Kaivan

AU - Aghamohammadzadeh, Reza

AU - Luckie, Matthew

AU - Brownrigg, Jack

AU - Alam, Uazman

AU - Khattar, Rajdeep

AU - Malik, Rayaz A

AU - Heagerty, Anthony M

AU - Greenstein, Adam S

N1 - © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

PY - 2017/4/11

Y1 - 2017/4/11

N2 - BACKGROUND: Small artery pathophysiology is frequently invoked as a cause of obesity-related diastolic heart failure. However, evidence to support this hypothesis is scant, particularly in humans.METHODS AND RESULTS: To address this, we studied human small artery structure and function in obesity and looked for correlations between vascular parameters and diastolic function. Seventeen obese patients with metabolic syndrome and 5 control participants underwent echocardiography and subcutaneous gluteal fat biopsy. Small arteries were isolated from the biopsy and pressure myography was used to study endothelial function and wall structure. In comparison with the control group, small arteries from obese participants exhibited significant endothelial dysfunction, assessed as the vasodilatory response to acetylcholine and also pathological growth of the wall. For the obese participants, multiple regression analysis revealed an association between left atrial volume and both the small artery wall thickness (β=0.718, P=0.02) and wall-to-lumen ratio (β=0.605, P=0.02). Furthermore, the E:E' ratio was associated with wall-to-lumen ratio (β=0.596, P=0.02) and inversely associated with interleukin-6 (β=-0.868, P=0.03). By contrast, endothelial function did not correlate with any of the echocardiographic parameters studied.CONCLUSIONS: Although the small arteries studied were not cardiac in origin, our results support a role for small artery remodeling in the development of diastolic dysfunction in humans. Further direct examination of the structure and function of the myocardial resistance vasculature is now warranted, to elucidate the temporal association between metabolic risk factors, small artery injury, and diastolic impairment.

AB - BACKGROUND: Small artery pathophysiology is frequently invoked as a cause of obesity-related diastolic heart failure. However, evidence to support this hypothesis is scant, particularly in humans.METHODS AND RESULTS: To address this, we studied human small artery structure and function in obesity and looked for correlations between vascular parameters and diastolic function. Seventeen obese patients with metabolic syndrome and 5 control participants underwent echocardiography and subcutaneous gluteal fat biopsy. Small arteries were isolated from the biopsy and pressure myography was used to study endothelial function and wall structure. In comparison with the control group, small arteries from obese participants exhibited significant endothelial dysfunction, assessed as the vasodilatory response to acetylcholine and also pathological growth of the wall. For the obese participants, multiple regression analysis revealed an association between left atrial volume and both the small artery wall thickness (β=0.718, P=0.02) and wall-to-lumen ratio (β=0.605, P=0.02). Furthermore, the E:E' ratio was associated with wall-to-lumen ratio (β=0.596, P=0.02) and inversely associated with interleukin-6 (β=-0.868, P=0.03). By contrast, endothelial function did not correlate with any of the echocardiographic parameters studied.CONCLUSIONS: Although the small arteries studied were not cardiac in origin, our results support a role for small artery remodeling in the development of diastolic dysfunction in humans. Further direct examination of the structure and function of the myocardial resistance vasculature is now warranted, to elucidate the temporal association between metabolic risk factors, small artery injury, and diastolic impairment.

KW - diastolic dysfunction

KW - endothelial dysfunction

KW - heart failure

KW - obesity

KW - vascular remodeling

U2 - 10.1161/JAHA.116.004603

DO - 10.1161/JAHA.116.004603

M3 - Article

VL - 6

JO - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

JF - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

SN - 2047-9980

IS - 4

M1 - e004603

ER -