A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosisCitation formats

  • External authors:
  • Anisha Doshi
  • Richelle Scott
  • David Paling
  • David Rog
  • Jeremy Chataway
  • Menno Schoonheim

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A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis. / Jandric, Danka; Doshi, Anisha; Scott, Richelle; Paling, David; Rog, David; Chataway, Jeremy; Schoonheim, Menno; Parker, Geoff; Muhlert, Nils.

In: Brain Connectivity, 12.08.2021.

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Jandric, Danka ; Doshi, Anisha ; Scott, Richelle ; Paling, David ; Rog, David ; Chataway, Jeremy ; Schoonheim, Menno ; Parker, Geoff ; Muhlert, Nils. / A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis. In: Brain Connectivity. 2021.

Bibtex

@article{635b0cbb37c9404cab43e8095831cd26,
title = "A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis",
abstract = "Introduction: Cognitive impairment in multiple sclerosis (MS) is increasingly being investigated with resting state functional MRI (rs-fMRI) functional connectivity (FC) . However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Methods: Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Results: Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. Discussion: These results indicate an urgent need for greater standardisation in the field – in terms of the choice of MRI analysis and the definition of cognitive impairment. This will allow us to use rs-fMRI FC as a biomarker in future clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS.",
author = "Danka Jandric and Anisha Doshi and Richelle Scott and David Paling and David Rog and Jeremy Chataway and Menno Schoonheim and Geoff Parker and Nils Muhlert",
year = "2021",
month = aug,
day = "12",
doi = "10.1089/brain.2021.0104",
language = "English",
journal = "Brain connectivity",
issn = "2158-0022",
publisher = "Mary Ann Liebert Incorporated",

}

RIS

TY - JOUR

T1 - A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis

AU - Jandric, Danka

AU - Doshi, Anisha

AU - Scott, Richelle

AU - Paling, David

AU - Rog, David

AU - Chataway, Jeremy

AU - Schoonheim, Menno

AU - Parker, Geoff

AU - Muhlert, Nils

PY - 2021/8/12

Y1 - 2021/8/12

N2 - Introduction: Cognitive impairment in multiple sclerosis (MS) is increasingly being investigated with resting state functional MRI (rs-fMRI) functional connectivity (FC) . However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Methods: Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Results: Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. Discussion: These results indicate an urgent need for greater standardisation in the field – in terms of the choice of MRI analysis and the definition of cognitive impairment. This will allow us to use rs-fMRI FC as a biomarker in future clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS.

AB - Introduction: Cognitive impairment in multiple sclerosis (MS) is increasingly being investigated with resting state functional MRI (rs-fMRI) functional connectivity (FC) . However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Methods: Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Results: Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. Discussion: These results indicate an urgent need for greater standardisation in the field – in terms of the choice of MRI analysis and the definition of cognitive impairment. This will allow us to use rs-fMRI FC as a biomarker in future clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS.

U2 - 10.1089/brain.2021.0104

DO - 10.1089/brain.2021.0104

M3 - Article

JO - Brain connectivity

JF - Brain connectivity

SN - 2158-0022

ER -