A switchable [2]rotaxane asymmetric organocatalyst that utilizes an acyclic chiral secondary amine

Research output: Contribution to journalArticle

  • Authors:
  • Victor Blanco
  • David A. Leigh
  • Vanesa Marcos
  • José A. Morales-Serna
  • Alina L. Nussbaumer


A rotaxane-based switchable asymmetric organocatalyst has been synthesized in which the change of the position of the macrocycle reveals or conceals an acyclic, yet still highly effective, chiral organocatalytic group. This allows control over both the rate and stereochemical outcome of a catalyzed asymmetric Michael addition. © 2014 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4905-4908
Number of pages3
JournalJournal of the American Chemical Society
Issue number13
StatePublished - 2 Apr 2014