A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.Citation formats

  • Authors:
  • CJC Johnston
  • DJ Smyth
  • RB Kodali
  • MPJ White
  • Y Harcus
  • And 9 others
  • External authors:
  • KJ Filbey
  • JP Hewitson
  • CS Hinck
  • A Ivens
  • AM Kemter
  • AO Kildemoes
  • Bihan T Le
  • DC Soares
  • RM Maizels

Standard

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. / Johnston, CJC; Smyth, DJ; Kodali, RB; White, MPJ; Harcus, Y; Filbey, KJ; Hewitson, JP; Hinck, CS; Ivens, A; Kemter, AM; Kildemoes, AO; Le, Bihan T; Soares, DC; Maizels, RM.

In: Nature Communications, 23.11.2017.

Research output: Contribution to journalArticle

Harvard

Johnston, CJC, Smyth, DJ, Kodali, RB, White, MPJ, Harcus, Y, Filbey, KJ, Hewitson, JP, Hinck, CS, Ivens, A, Kemter, AM, Kildemoes, AO, Le, BT, Soares, DC & Maizels, RM 2017, 'A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.', Nature Communications. https://doi.org/10.1038/s41467-017-01886-6

APA

Johnston, CJC., Smyth, DJ., Kodali, RB., White, MPJ., Harcus, Y., Filbey, KJ., ... Maizels, RM. (2017). A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications. https://doi.org/10.1038/s41467-017-01886-6

Vancouver

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ et al. A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications. 2017 Nov 23. https://doi.org/10.1038/s41467-017-01886-6

Author

Johnston, CJC ; Smyth, DJ ; Kodali, RB ; White, MPJ ; Harcus, Y ; Filbey, KJ ; Hewitson, JP ; Hinck, CS ; Ivens, A ; Kemter, AM ; Kildemoes, AO ; Le, Bihan T ; Soares, DC ; Maizels, RM. / A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. In: Nature Communications. 2017.

Bibtex

@article{ad6e920a523f49e6a36165aaab1d7c20,
title = "A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.",
abstract = "Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.",
author = "CJC Johnston and DJ Smyth and RB Kodali and MPJ White and Y Harcus and KJ Filbey and JP Hewitson and CS Hinck and A Ivens and AM Kemter and AO Kildemoes and Le, {Bihan T} and DC Soares and RM Maizels",
year = "2017",
month = "11",
day = "23",
doi = "10.1038/s41467-017-01886-6",
language = "English",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

AU - Johnston, CJC

AU - Smyth, DJ

AU - Kodali, RB

AU - White, MPJ

AU - Harcus, Y

AU - Filbey, KJ

AU - Hewitson, JP

AU - Hinck, CS

AU - Ivens, A

AU - Kemter, AM

AU - Kildemoes, AO

AU - Le, Bihan T

AU - Soares, DC

AU - Maizels, RM

PY - 2017/11/23

Y1 - 2017/11/23

N2 - Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.

AB - Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.

U2 - 10.1038/s41467-017-01886-6

DO - 10.1038/s41467-017-01886-6

M3 - Article

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -