A Six-Crossing [2]Catenane with Twisted Rings (a Molecular 6-3-2 Link), and a Molecular Granny Knot

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  • Authors:
  • David Leigh
  • Jonathan Danon
  • Simone Pisano
  • Alberto Valero
  • Iñigo J. Vitorica-yrezabal

Abstract

A molecular 6_3^2 link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 31#31 granny knot (a composite knot made up of two trefoil tangles of the same handedness) were constructed by ring‐closing olefin metathesis of an iron(II)‐coordinated 2×2 interwoven grid. The connections were directed by pendant phenyl groups to be between proximal ligand ends on the same faces of the grid. The 6_3^2 link was separated from the topoisomeric granny knot by recycling size‐exclusion chromatography. The identity of each topoisomer was determined by tandem mass spectrometry and the structure of the 6_3^2 link confirmed by X‐ray crystallography, which revealed two 82‐membered macrocycles, each in figure‐of‐eight conformations, linked through both pairs of loops.

Bibliographical metadata

Original languageEnglish
JournalAngewandte Chemie International Edition
Early online date28 Aug 2018
DOIs
Publication statusPublished - 2018

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