A Review of Approaches to 18F Radiolabelling Affinity Peptide & ProteinsCitation formats

Standard

A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins. / Morris, Olivia; Fairclough, Michael; Grigg, J.; Prenant, Christian; Mcmahon, Adam.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, No. 1, 2019, p. 4-23.

Research output: Contribution to journal › Article

Harvard

Morris, O, Fairclough, M, Grigg, J, Prenant, C & Mcmahon, A 2019, 'A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 62, no. 1, pp. 4-23. https://doi.org/10.1002/jlcr.3634

APA

Morris, O., Fairclough, M., Grigg, J., Prenant, C., & Mcmahon, A. (2019). A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins. Journal of Labelled Compounds and Radiopharmaceuticals, 62(1), 4-23. https://doi.org/10.1002/jlcr.3634

Vancouver

Morris O, Fairclough M, Grigg J, Prenant C, Mcmahon A. A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins. Journal of Labelled Compounds and Radiopharmaceuticals. 2019;62(1):4-23. https://doi.org/10.1002/jlcr.3634

Author

Morris, Olivia ; Fairclough, Michael ; Grigg, J. ; Prenant, Christian ; Mcmahon, Adam. / A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2019 ; Vol. 62, No. 1. pp. 4-23.

Bibtex

@article{29879604d10d4431b7243a9d5f0e10bd,
title = "A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins",
abstract = "Affinity peptide and protein- (APP) based radiotracers are an increasingly popular class of radiotracer in positron emission tomography (PET), which was once dominated by the use of small molecule radiotracers. Radiolabelled monoclonal antibodies (mAbs) are important examples of APPs yet a preference for smaller APPs, which exhibit fast pharmacokinetics and permit rapid PET aided diagnosis, has become apparent. 18F exhibits favourable physical characteristics for APP radiolabelling and has been described as an ideal PET radionuclide. Notwithstanding, 18F radiolabelling of APP is challenging and this is echoed in the literature where a number of diverse approaches have been adopted. This review seeks to assess and compare the approaches taken to 18F APP radiolabelling with the intention of highlighting trends within this expanding field. Generic themes have emerged in the literature, namely the use of mild radiolabelling conditions, a preference of site-specific methodologies with an impetus for short, automated procedures which produce high-yielding [18F]APPs.",
keywords = "affibody, automation, monoclonal antibodies, nanobody, proteins and peptides, radiolabelling",
author = "Olivia Morris and Michael Fairclough and J. Grigg and Christian Prenant and Adam Mcmahon",
year = "2019",
doi = "10.1002/jlcr.3634",
language = "English",
volume = "62",
pages = "4--23",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley & Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - A Review of Approaches to 18F Radiolabelling Affinity Peptide & Proteins

AU - Morris, Olivia

AU - Fairclough, Michael

AU - Grigg, J.

AU - Prenant, Christian

AU - Mcmahon, Adam

PY - 2019

Y1 - 2019

N2 - Affinity peptide and protein- (APP) based radiotracers are an increasingly popular class of radiotracer in positron emission tomography (PET), which was once dominated by the use of small molecule radiotracers. Radiolabelled monoclonal antibodies (mAbs) are important examples of APPs yet a preference for smaller APPs, which exhibit fast pharmacokinetics and permit rapid PET aided diagnosis, has become apparent. 18F exhibits favourable physical characteristics for APP radiolabelling and has been described as an ideal PET radionuclide. Notwithstanding, 18F radiolabelling of APP is challenging and this is echoed in the literature where a number of diverse approaches have been adopted. This review seeks to assess and compare the approaches taken to 18F APP radiolabelling with the intention of highlighting trends within this expanding field. Generic themes have emerged in the literature, namely the use of mild radiolabelling conditions, a preference of site-specific methodologies with an impetus for short, automated procedures which produce high-yielding [18F]APPs.

AB - Affinity peptide and protein- (APP) based radiotracers are an increasingly popular class of radiotracer in positron emission tomography (PET), which was once dominated by the use of small molecule radiotracers. Radiolabelled monoclonal antibodies (mAbs) are important examples of APPs yet a preference for smaller APPs, which exhibit fast pharmacokinetics and permit rapid PET aided diagnosis, has become apparent. 18F exhibits favourable physical characteristics for APP radiolabelling and has been described as an ideal PET radionuclide. Notwithstanding, 18F radiolabelling of APP is challenging and this is echoed in the literature where a number of diverse approaches have been adopted. This review seeks to assess and compare the approaches taken to 18F APP radiolabelling with the intention of highlighting trends within this expanding field. Generic themes have emerged in the literature, namely the use of mild radiolabelling conditions, a preference of site-specific methodologies with an impetus for short, automated procedures which produce high-yielding [18F]APPs.

KW - affibody

KW - automation

KW - monoclonal antibodies

KW - nanobody

KW - proteins and peptides

KW - radiolabelling

U2 - 10.1002/jlcr.3634

DO - 10.1002/jlcr.3634

M3 - Article

VL - 62

SP - 4

EP - 23

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 1

ER -