A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapyCitation formats

  • External authors:
  • C. J. Talbot
  • G. A. Tanteles
  • G. C. Barnett
  • N. G. Burnet
  • J. Chang-Claude
  • C. E. Coles
  • S. Davidson
  • A. M. Dunning
  • J. Mills
  • R. J S Murray
  • O. Popanda
  • P. Seibold
  • J. R. Yarnold
  • R. P. Symonds

Standard

A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. / Talbot, C. J.; Tanteles, G. A.; Barnett, G. C.; Burnet, N. G.; Chang-Claude, J.; Coles, C. E.; Davidson, S.; Dunning, A. M.; Mills, J.; Murray, R. J S; Popanda, O.; Seibold, P.; West, C. M L; Yarnold, J. R.; Symonds, R. P.

In: British Journal of Cancer, Vol. 107, No. 4, 07.08.2012, p. 748-753.

Research output: Contribution to journalArticle

Harvard

Talbot, CJ, Tanteles, GA, Barnett, GC, Burnet, NG, Chang-Claude, J, Coles, CE, Davidson, S, Dunning, AM, Mills, J, Murray, RJS, Popanda, O, Seibold, P, West, CML, Yarnold, JR & Symonds, RP 2012, 'A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy', British Journal of Cancer, vol. 107, no. 4, pp. 748-753. https://doi.org/10.1038/bjc.2012.290

APA

Talbot, C. J., Tanteles, G. A., Barnett, G. C., Burnet, N. G., Chang-Claude, J., Coles, C. E., ... Symonds, R. P. (2012). A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. British Journal of Cancer, 107(4), 748-753. https://doi.org/10.1038/bjc.2012.290

Vancouver

Talbot CJ, Tanteles GA, Barnett GC, Burnet NG, Chang-Claude J, Coles CE et al. A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. British Journal of Cancer. 2012 Aug 7;107(4):748-753. https://doi.org/10.1038/bjc.2012.290

Author

Talbot, C. J. ; Tanteles, G. A. ; Barnett, G. C. ; Burnet, N. G. ; Chang-Claude, J. ; Coles, C. E. ; Davidson, S. ; Dunning, A. M. ; Mills, J. ; Murray, R. J S ; Popanda, O. ; Seibold, P. ; West, C. M L ; Yarnold, J. R. ; Symonds, R. P. / A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. In: British Journal of Cancer. 2012 ; Vol. 107, No. 4. pp. 748-753.

Bibtex

@article{7d64e1e2ccba4915a97d780caa86483b,
title = "A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy",
abstract = "Background: Response to radiotherapy varies between individuals both in terms of efficacy and adverse reactions. Finding genetic determinants of radiation response would allow the tailoring of the treatment, either by altering the radiation dose or by surgery. Despite a growing number of studies in radiogenomics, there are no well-replicated genetic association results.Methods:We carried out a candidate gene association study and replicated the result using three additional large cohorts, a total of 2036 women scored for adverse reactions to radiotherapy for breast cancer.Results:Genetic variation near the tumour necrosis factor alpha gene is shown to affect several clinical endpoints including breast induration, telangiectasia and overall toxicity. In the combined analysis homozygosity for the rare allele increases overall toxicity (P=0.001) and chance of being in the upper quartile of risk with odds ratio of 2.46 (95{\%} confidence interval 1.52-3.98).Conclusion:We have identified that alleles of the class III major histocompatibility complex region associate with overall radiotherapy toxicity in breast cancer patients by using internal replication through a staged design. This is the first well-replicated report of a genetic predictor for radiotherapy reactions. {\circledC} 2012 Cancer Research UK All rights reserved.",
keywords = "breast cancer, genetics, normal tissue radiation injury, tumour necrosis factor alpha (TNFα)",
author = "Talbot, {C. J.} and Tanteles, {G. A.} and Barnett, {G. C.} and Burnet, {N. G.} and J. Chang-Claude and Coles, {C. E.} and S. Davidson and Dunning, {A. M.} and J. Mills and Murray, {R. J S} and O. Popanda and P. Seibold and West, {C. M L} and Yarnold, {J. R.} and Symonds, {R. P.}",
year = "2012",
month = "8",
day = "7",
doi = "10.1038/bjc.2012.290",
language = "English",
volume = "107",
pages = "748--753",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "4",

}

RIS

TY - JOUR

T1 - A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy

AU - Talbot, C. J.

AU - Tanteles, G. A.

AU - Barnett, G. C.

AU - Burnet, N. G.

AU - Chang-Claude, J.

AU - Coles, C. E.

AU - Davidson, S.

AU - Dunning, A. M.

AU - Mills, J.

AU - Murray, R. J S

AU - Popanda, O.

AU - Seibold, P.

AU - West, C. M L

AU - Yarnold, J. R.

AU - Symonds, R. P.

PY - 2012/8/7

Y1 - 2012/8/7

N2 - Background: Response to radiotherapy varies between individuals both in terms of efficacy and adverse reactions. Finding genetic determinants of radiation response would allow the tailoring of the treatment, either by altering the radiation dose or by surgery. Despite a growing number of studies in radiogenomics, there are no well-replicated genetic association results.Methods:We carried out a candidate gene association study and replicated the result using three additional large cohorts, a total of 2036 women scored for adverse reactions to radiotherapy for breast cancer.Results:Genetic variation near the tumour necrosis factor alpha gene is shown to affect several clinical endpoints including breast induration, telangiectasia and overall toxicity. In the combined analysis homozygosity for the rare allele increases overall toxicity (P=0.001) and chance of being in the upper quartile of risk with odds ratio of 2.46 (95% confidence interval 1.52-3.98).Conclusion:We have identified that alleles of the class III major histocompatibility complex region associate with overall radiotherapy toxicity in breast cancer patients by using internal replication through a staged design. This is the first well-replicated report of a genetic predictor for radiotherapy reactions. © 2012 Cancer Research UK All rights reserved.

AB - Background: Response to radiotherapy varies between individuals both in terms of efficacy and adverse reactions. Finding genetic determinants of radiation response would allow the tailoring of the treatment, either by altering the radiation dose or by surgery. Despite a growing number of studies in radiogenomics, there are no well-replicated genetic association results.Methods:We carried out a candidate gene association study and replicated the result using three additional large cohorts, a total of 2036 women scored for adverse reactions to radiotherapy for breast cancer.Results:Genetic variation near the tumour necrosis factor alpha gene is shown to affect several clinical endpoints including breast induration, telangiectasia and overall toxicity. In the combined analysis homozygosity for the rare allele increases overall toxicity (P=0.001) and chance of being in the upper quartile of risk with odds ratio of 2.46 (95% confidence interval 1.52-3.98).Conclusion:We have identified that alleles of the class III major histocompatibility complex region associate with overall radiotherapy toxicity in breast cancer patients by using internal replication through a staged design. This is the first well-replicated report of a genetic predictor for radiotherapy reactions. © 2012 Cancer Research UK All rights reserved.

KW - breast cancer

KW - genetics

KW - normal tissue radiation injury

KW - tumour necrosis factor alpha (TNFα)

U2 - 10.1038/bjc.2012.290

DO - 10.1038/bjc.2012.290

M3 - Article

VL - 107

SP - 748

EP - 753

JO - BJC

JF - BJC

SN - 0007-0920

IS - 4

ER -