A perspective on conformational control of electron transfer in nitric oxide synthases

Research output: Contribution to journalArticle

Abstract

This perspective reviews single molecule and ensemble fluorescence spectroscopy studies of the three tissue specific nitric oxide synthase (NOS) isoenzymes and the related diflavin oxidoreductase cytochrome P450 reductase. The focus is on the role of protein dynamics and the protein conformational landscape and we discuss how recent fluorescence-based studies have helped in illustrating how the nature of the NOS conformational landscape relates to enzyme turnover and catalysis.

Bibliographical metadata

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalNitric Oxide: Biology and Chemistry
Volume63
Early online date9 Sep 2016
DOIs
StatePublished - 28 Feb 2017