A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

Research output: Contribution to journalArticle

  • Authors:
  • Gabriella Ieronimo
  • Giovanni Palmisano
  • Angelo Maspero
  • Alessandro Marzorati
  • Luca Scapinello
  • And 7 others
  • External authors:
  • Norberto Masciocchi
  • Giancarlo Cravotto
  • Alessandro Barge
  • Marco Simonetti
  • Keshav Lalit Ameta
  • Kenneth M. Nicholas
  • Andrea Penoni

Abstract

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)6853-6859
Number of pages6
JournalOrganic & biomolecular chemistry
Volume16
Issue number38
Early online date24 Jul 2018
DOIs
Publication statusPublished - 2018