A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

Research output: Contribution to journalArticle

  • External authors:
  • Fabien Brette
  • Caroline Cros
  • John Incardona
  • Nathaniel Scholz
  • Barbara A. Block

Abstract

The Deepwater Horizon disaster drew global attention to the toxicity of crude oil and the potential for adverse health effects amongst marine life and spill responders in the northern Gulf of Mexico. The blowout released complex mixtures of polycyclic aromatic hydrocarbons (PAHs) into critical pelagic spawning habitats for tunas, billfishes, and other ecologically important top predators. Crude oil disrupts cardiac function and has been associated with heart malformations in developing fish. However, the precise identity of cardiotoxic PAHs, and the mechanisms underlying contractile dysfunction are not known. Here we show that phenanthrene, a PAH with a benzene 3-ring structure, is the key moiety disrupting the physiology of heart muscle cells. Phenanthrene is a ubiquitous pollutant in water and air, and the cellular targets for this compound are highly conserved across vertebrates. Our findings
therefore suggest that phenanthrenes may be a major worldwide cause of vertebrate cardiac dysfunction.

Bibliographical metadata

Original languageEnglish
JournalScientific Reports
Early online date31 Jan 2017
DOIs
StatePublished - 2017