A new generation of smart amine donors for transaminase-mediated biotransformations

Research output: Contribution to journalArticle

Abstract

The application of ω-transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effective approach using low equivalents of the new diamine donor, cadaverine, which enables high conversions of challenging substrates to the corresponding chiral amines in excellent ee. This approach paves the way for the design of self-sufficient fermentation processes combining transaminase biotransformations with existing strategies for cadaverine production by decarboxylation of endogenous lysine.

Bibliographical metadata

Original languageEnglish
Pages (from-to)12692-12695
Number of pages4
JournalChemistry: A European Journal
Volume22
Issue number36
Early online date3 Aug 2016
DOIs
StatePublished - 22 Aug 2016