A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

Research output: Contribution to journalArticle

  • External authors:
  • Gavin Miller
  • Karl Broberg
  • C Rudd
  • Madeleine Helliwell

Abstract

D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Bibliographical metadata

Original languageEnglish
Pages (from-to)11208-11219
JournalOrganic & biomolecular chemistry
Volume13
Issue number46
DOIs
StatePublished - 9 Sep 2015