A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinomaCitation formats

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A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. / Sheridan, Mary T.; Cooper, Rachel A.; West, Catharine M L.

In: International Journal of Radiation Oncology Biology Physics, Vol. 44, No. 3, 01.06.1999, p. 507-512.

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Sheridan, MT, Cooper, RA & West, CML 1999, 'A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma', International Journal of Radiation Oncology Biology Physics, vol. 44, no. 3, pp. 507-512. https://doi.org/10.1016/S0360-3016(99)00081-4

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Sheridan, Mary T. ; Cooper, Rachel A. ; West, Catharine M L. / A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. In: International Journal of Radiation Oncology Biology Physics. 1999 ; Vol. 44, No. 3. pp. 507-512.

Bibtex

@article{640afa1541fa4f5bab094737f20b3b19,
title = "A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma",
abstract = "Purpose: A retrospective study was made of the role of apoptosis in determining radiotherapy outcome in 39 adenocarcinoma of the cervix. A comparison was also made of the detection of apoptosis by morphology and the TdT dUtp nick end-labeling (TUNEL) assay. Methods and Materials: The level of apoptosis was assessed in paraffin-embedded sections by cell morphology, the TUNEL assay, and a combination of the two. A total of 2,000 cells were counted per section, to obtain apoptotic (AI) and mitotic (MI) indices. Results: Patients with a high AI had a higher survival rate than those with a low AI, however, the difference was not significant. Using a ratio of apoptosis to proliferation indices, patients with an AI:MI > median had significantly better survival than those with AI:MI <median. This was true where the AI was quantified by morphology alone (p = 0.030) or in combination with the TUNEL assay (p = 0.008). Where the AI was quantified by a combination of morphology and TUNEL, the 5-year survival rates for women with AI:MI greater or less than the median were 81% and 25%, respectively. Conclusion: A high ratio of AI:MI in adenocarcinoma of the cervix indicates a good prognosis. A combination of the TUNEL assay and morphology provided the best discrimination between outcome groups.",
keywords = "Apoptosis, Cervix, Proliferation, Survival, TUNEL",
author = "Sheridan, {Mary T.} and Cooper, {Rachel A.} and West, {Catharine M L}",
year = "1999",
month = jun,
day = "1",
doi = "10.1016/S0360-3016(99)00081-4",
language = "English",
volume = "44",
pages = "507--512",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma

AU - Sheridan, Mary T.

AU - Cooper, Rachel A.

AU - West, Catharine M L

PY - 1999/6/1

Y1 - 1999/6/1

N2 - Purpose: A retrospective study was made of the role of apoptosis in determining radiotherapy outcome in 39 adenocarcinoma of the cervix. A comparison was also made of the detection of apoptosis by morphology and the TdT dUtp nick end-labeling (TUNEL) assay. Methods and Materials: The level of apoptosis was assessed in paraffin-embedded sections by cell morphology, the TUNEL assay, and a combination of the two. A total of 2,000 cells were counted per section, to obtain apoptotic (AI) and mitotic (MI) indices. Results: Patients with a high AI had a higher survival rate than those with a low AI, however, the difference was not significant. Using a ratio of apoptosis to proliferation indices, patients with an AI:MI > median had significantly better survival than those with AI:MI <median. This was true where the AI was quantified by morphology alone (p = 0.030) or in combination with the TUNEL assay (p = 0.008). Where the AI was quantified by a combination of morphology and TUNEL, the 5-year survival rates for women with AI:MI greater or less than the median were 81% and 25%, respectively. Conclusion: A high ratio of AI:MI in adenocarcinoma of the cervix indicates a good prognosis. A combination of the TUNEL assay and morphology provided the best discrimination between outcome groups.

AB - Purpose: A retrospective study was made of the role of apoptosis in determining radiotherapy outcome in 39 adenocarcinoma of the cervix. A comparison was also made of the detection of apoptosis by morphology and the TdT dUtp nick end-labeling (TUNEL) assay. Methods and Materials: The level of apoptosis was assessed in paraffin-embedded sections by cell morphology, the TUNEL assay, and a combination of the two. A total of 2,000 cells were counted per section, to obtain apoptotic (AI) and mitotic (MI) indices. Results: Patients with a high AI had a higher survival rate than those with a low AI, however, the difference was not significant. Using a ratio of apoptosis to proliferation indices, patients with an AI:MI > median had significantly better survival than those with AI:MI <median. This was true where the AI was quantified by morphology alone (p = 0.030) or in combination with the TUNEL assay (p = 0.008). Where the AI was quantified by a combination of morphology and TUNEL, the 5-year survival rates for women with AI:MI greater or less than the median were 81% and 25%, respectively. Conclusion: A high ratio of AI:MI in adenocarcinoma of the cervix indicates a good prognosis. A combination of the TUNEL assay and morphology provided the best discrimination between outcome groups.

KW - Apoptosis

KW - Cervix

KW - Proliferation

KW - Survival

KW - TUNEL

U2 - 10.1016/S0360-3016(99)00081-4

DO - 10.1016/S0360-3016(99)00081-4

M3 - Article

VL - 44

SP - 507

EP - 512

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 3

ER -