A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptakeCitation formats

  • External authors:
  • Mei Yang
  • Momoyo Wada
  • Minfang Zhang
  • Ryota Yuge
  • Sumio Iijima
  • Mitsutoshi Masuda
  • Masako Yudasaka

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A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake. / Yang, Mei; Wada, Momoyo; Zhang, Minfang; Kostarelos, Kostas; Yuge, Ryota; Iijima, Sumio; Masuda, Mitsutoshi; Yudasaka, Masako.

In: Acta Biomaterialia, Vol. 9, No. 1, 01.2013, p. 4744-4753.

Research output: Contribution to journalArticle

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Yang, M, Wada, M, Zhang, M, Kostarelos, K, Yuge, R, Iijima, S, Masuda, M & Yudasaka, M 2013, 'A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake', Acta Biomaterialia, vol. 9, no. 1, pp. 4744-4753. https://doi.org/10.1016/j.actbio.2012.09.012

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Author

Yang, Mei ; Wada, Momoyo ; Zhang, Minfang ; Kostarelos, Kostas ; Yuge, Ryota ; Iijima, Sumio ; Masuda, Mitsutoshi ; Yudasaka, Masako. / A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake. In: Acta Biomaterialia. 2013 ; Vol. 9, No. 1. pp. 4744-4753.

Bibtex

@article{2eccfdaa98314082b980ae3e4def6db7,
title = "A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake",
abstract = "Amphiphilic lipid-poly(ethylene glycol) (LPEG) is widely used for the noncovalent functionalization of graphene nanomaterials (GNMs) to improve their dispersion in aqueous solutions for biomedical applications. However, not much is known about the detachment of LPEGs from GNMs and macrophage uptake of dispersed GNMs in relation to the alkyl chain coverage, the PEG coverage, and the linker group in LPEGs. In this study we examined these relationships using single walled carbon nanohorns (SWCNHs). The high coverage of PEG rather than that of alkyl chains was dominant in suppressing the detachment of LPEGs from SWCNHs in protein-containing physiological solution. Correspondingly, the quantity of LPEG-covered SWCNHs (LPEG-SWCNHs) taken up by macrophages decreased at a high PEG coverage. Our study also demonstrated an effect of the ionic group in LPEG on SWCNH uptake into macrophages. A phosphate anionic group in the LPEG induced lower alkyl chain coverage and easy detachment of the LPEG, however, the negative surface charge of LPEG-SWCNHs reduced the uptake of SWCNHs by macrophages. {\circledC} 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.",
keywords = "Detachment, Lipid-poly(ethylene glycol), Macrophage uptake, Noncovalent functionalization, Single-walled carbon nanohorn",
author = "Mei Yang and Momoyo Wada and Minfang Zhang and Kostas Kostarelos and Ryota Yuge and Sumio Iijima and Mitsutoshi Masuda and Masako Yudasaka",
note = "Times Cited: 0 0",
year = "2013",
month = "1",
doi = "10.1016/j.actbio.2012.09.012",
language = "English",
volume = "9",
pages = "4744--4753",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake

AU - Yang, Mei

AU - Wada, Momoyo

AU - Zhang, Minfang

AU - Kostarelos, Kostas

AU - Yuge, Ryota

AU - Iijima, Sumio

AU - Masuda, Mitsutoshi

AU - Yudasaka, Masako

N1 - Times Cited: 0 0

PY - 2013/1

Y1 - 2013/1

N2 - Amphiphilic lipid-poly(ethylene glycol) (LPEG) is widely used for the noncovalent functionalization of graphene nanomaterials (GNMs) to improve their dispersion in aqueous solutions for biomedical applications. However, not much is known about the detachment of LPEGs from GNMs and macrophage uptake of dispersed GNMs in relation to the alkyl chain coverage, the PEG coverage, and the linker group in LPEGs. In this study we examined these relationships using single walled carbon nanohorns (SWCNHs). The high coverage of PEG rather than that of alkyl chains was dominant in suppressing the detachment of LPEGs from SWCNHs in protein-containing physiological solution. Correspondingly, the quantity of LPEG-covered SWCNHs (LPEG-SWCNHs) taken up by macrophages decreased at a high PEG coverage. Our study also demonstrated an effect of the ionic group in LPEG on SWCNH uptake into macrophages. A phosphate anionic group in the LPEG induced lower alkyl chain coverage and easy detachment of the LPEG, however, the negative surface charge of LPEG-SWCNHs reduced the uptake of SWCNHs by macrophages. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

AB - Amphiphilic lipid-poly(ethylene glycol) (LPEG) is widely used for the noncovalent functionalization of graphene nanomaterials (GNMs) to improve their dispersion in aqueous solutions for biomedical applications. However, not much is known about the detachment of LPEGs from GNMs and macrophage uptake of dispersed GNMs in relation to the alkyl chain coverage, the PEG coverage, and the linker group in LPEGs. In this study we examined these relationships using single walled carbon nanohorns (SWCNHs). The high coverage of PEG rather than that of alkyl chains was dominant in suppressing the detachment of LPEGs from SWCNHs in protein-containing physiological solution. Correspondingly, the quantity of LPEG-covered SWCNHs (LPEG-SWCNHs) taken up by macrophages decreased at a high PEG coverage. Our study also demonstrated an effect of the ionic group in LPEG on SWCNH uptake into macrophages. A phosphate anionic group in the LPEG induced lower alkyl chain coverage and easy detachment of the LPEG, however, the negative surface charge of LPEG-SWCNHs reduced the uptake of SWCNHs by macrophages. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

KW - Detachment

KW - Lipid-poly(ethylene glycol)

KW - Macrophage uptake

KW - Noncovalent functionalization

KW - Single-walled carbon nanohorn

U2 - 10.1016/j.actbio.2012.09.012

DO - 10.1016/j.actbio.2012.09.012

M3 - Article

VL - 9

SP - 4744

EP - 4753

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 1

ER -