A heparin-functionalized woven stent graft for endovascular exclusionCitation formats

  • External authors:
  • Zekun Liu
  • Zhaozhu Zheng
  • Kaili Chen
  • Xiaoqin Wang
  • Gang Li

Standard

A heparin-functionalized woven stent graft for endovascular exclusion. / Liu, Zekun; Zheng, Zhaozhu; Chen, Kaili; Li, Yi; Wang, Xiaoqin; Li, Gang.

In: Colloids and Surfaces B: Biointerfaces, Vol. 180, 01.08.2019, p. 118-126.

Research output: Contribution to journalArticle

Harvard

Liu, Z, Zheng, Z, Chen, K, Li, Y, Wang, X & Li, G 2019, 'A heparin-functionalized woven stent graft for endovascular exclusion', Colloids and Surfaces B: Biointerfaces, vol. 180, pp. 118-126. https://doi.org/10.1016/j.colsurfb.2019.04.027

APA

Liu, Z., Zheng, Z., Chen, K., Li, Y., Wang, X., & Li, G. (2019). A heparin-functionalized woven stent graft for endovascular exclusion. Colloids and Surfaces B: Biointerfaces, 180, 118-126. https://doi.org/10.1016/j.colsurfb.2019.04.027

Vancouver

Liu Z, Zheng Z, Chen K, Li Y, Wang X, Li G. A heparin-functionalized woven stent graft for endovascular exclusion. Colloids and Surfaces B: Biointerfaces. 2019 Aug 1;180:118-126. https://doi.org/10.1016/j.colsurfb.2019.04.027

Author

Liu, Zekun ; Zheng, Zhaozhu ; Chen, Kaili ; Li, Yi ; Wang, Xiaoqin ; Li, Gang. / A heparin-functionalized woven stent graft for endovascular exclusion. In: Colloids and Surfaces B: Biointerfaces. 2019 ; Vol. 180. pp. 118-126.

Bibtex

@article{838f8895741248e89a82607794ea32b2,
title = "A heparin-functionalized woven stent graft for endovascular exclusion",
abstract = "With the increase of vascular diseases in recent years, it is of importance to develop an anti-occlusion stent graft, which can meet the requirements of transplants for a long term. In this paper, we describe a silk fibroin (SF)/heparin-functionalized bifurcated stent graft (BSG) using textile forming technology. The BSGs were prototyped based on seamless weaving technology, and the surface was modified with SF-loaded heparin under steam/air treatment to improve their patency. The physical properties such as thickness, water permeability, contact angle, mechanical properties, and in vitro drug release and coagulation time of the BSGs were examined. The results showed that heparin modification can improve its coagulation time, and the water permeability resistance of the BSGs reached 1.154 ± 0.854 mL/(cm2×min), while their thicknesses were just 0.085 ± 0.004 mm. The heparin release of the BSGs showed that the release time was prolonged upon steam treatment by means of the increase in the β-sheet structure and crystallinity of SF. The viability and attachment of human vascular smooth muscle (HVSM) cells cultured in the release of modified BSGs demonstrated that the modified BSGs could significantly inhibit the proliferation of HVSM cells. The heparin-functionalized BSG with satisfactory thickness, water permeability resistance and anti-occlusion function, which has potential applications in the treatment of vascular diseases.",
keywords = "Stent graft, Silk fibroin, Woven, Heparin, Surface functionalization",
author = "Zekun Liu and Zhaozhu Zheng and Kaili Chen and Yi Li and Xiaoqin Wang and Gang Li",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.colsurfb.2019.04.027",
language = "English",
volume = "180",
pages = "118--126",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - A heparin-functionalized woven stent graft for endovascular exclusion

AU - Liu, Zekun

AU - Zheng, Zhaozhu

AU - Chen, Kaili

AU - Li, Yi

AU - Wang, Xiaoqin

AU - Li, Gang

PY - 2019/8/1

Y1 - 2019/8/1

N2 - With the increase of vascular diseases in recent years, it is of importance to develop an anti-occlusion stent graft, which can meet the requirements of transplants for a long term. In this paper, we describe a silk fibroin (SF)/heparin-functionalized bifurcated stent graft (BSG) using textile forming technology. The BSGs were prototyped based on seamless weaving technology, and the surface was modified with SF-loaded heparin under steam/air treatment to improve their patency. The physical properties such as thickness, water permeability, contact angle, mechanical properties, and in vitro drug release and coagulation time of the BSGs were examined. The results showed that heparin modification can improve its coagulation time, and the water permeability resistance of the BSGs reached 1.154 ± 0.854 mL/(cm2×min), while their thicknesses were just 0.085 ± 0.004 mm. The heparin release of the BSGs showed that the release time was prolonged upon steam treatment by means of the increase in the β-sheet structure and crystallinity of SF. The viability and attachment of human vascular smooth muscle (HVSM) cells cultured in the release of modified BSGs demonstrated that the modified BSGs could significantly inhibit the proliferation of HVSM cells. The heparin-functionalized BSG with satisfactory thickness, water permeability resistance and anti-occlusion function, which has potential applications in the treatment of vascular diseases.

AB - With the increase of vascular diseases in recent years, it is of importance to develop an anti-occlusion stent graft, which can meet the requirements of transplants for a long term. In this paper, we describe a silk fibroin (SF)/heparin-functionalized bifurcated stent graft (BSG) using textile forming technology. The BSGs were prototyped based on seamless weaving technology, and the surface was modified with SF-loaded heparin under steam/air treatment to improve their patency. The physical properties such as thickness, water permeability, contact angle, mechanical properties, and in vitro drug release and coagulation time of the BSGs were examined. The results showed that heparin modification can improve its coagulation time, and the water permeability resistance of the BSGs reached 1.154 ± 0.854 mL/(cm2×min), while their thicknesses were just 0.085 ± 0.004 mm. The heparin release of the BSGs showed that the release time was prolonged upon steam treatment by means of the increase in the β-sheet structure and crystallinity of SF. The viability and attachment of human vascular smooth muscle (HVSM) cells cultured in the release of modified BSGs demonstrated that the modified BSGs could significantly inhibit the proliferation of HVSM cells. The heparin-functionalized BSG with satisfactory thickness, water permeability resistance and anti-occlusion function, which has potential applications in the treatment of vascular diseases.

KW - Stent graft

KW - Silk fibroin

KW - Woven

KW - Heparin

KW - Surface functionalization

U2 - 10.1016/j.colsurfb.2019.04.027

DO - 10.1016/j.colsurfb.2019.04.027

M3 - Article

VL - 180

SP - 118

EP - 126

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

ER -