A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Research output: Contribution to journalArticle

  • External authors:
  • Ildiko Horváth
  • Peter J Barnes
  • Stelios Loukides
  • Peter J Sterk
  • Marieann Högman
  • Anna-Carin Olin
  • Anton Amann
  • Balazs Antus
  • Eugenio Baraldi
  • Agnes W Boots
  • Lieuwe D Bos
  • Paul Brinkman
  • Caterina Bucca
  • Giovanna E Carpagnano
  • Massimo Corradi
  • Simona Cristescu
  • Johan C de Jongste
  • Anh-Tuan Dinh-Xuan
  • Edward Dompeling
  • Niki Fens
  • Jens M Hohlfeld
  • Olaf Holz
  • Quirijn Jöbsis
  • Kim Van De Kant
  • Hugo H Knobel
  • Konstantinos Kostikas
  • Lauri Lehtimäki
  • Jon Lundberg
  • Paolo Montuschi
  • Alain Van Muylem
  • Giorgio Pennazza
  • Petra Reinhold
  • Fabio L M Ricciardolo
  • Philippe Rosias
  • Marco Santonico
  • Marc P van der Schee
  • Frederik-Jan van Schooten
  • Antonio Spanevello
  • Thomy Tonia
  • Teunis J Vink


Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

Bibliographical metadata

Original languageEnglish
JournalThe European respiratory journal
Issue number4
Publication statusPublished - Apr 2017