A Dual Photoredox-Nickel Strategy for Remote Functionalization via Iminyl Radicals: Radical Ring-Opening–Arylation, –Vinylation and –Alkylation Cascades

Research output: Contribution to journalArticle

  • Authors:
  • Elizabeth Dauncey
  • Shashikant U. Dighe
  • James J Douglas
  • Daniele Leonori

Abstract

A divergent strategy for the remote arylation, vinylation and alkylation of nitriles is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its following ring-opening reaction. The distal nitrile radical is then engaged in nickel-based catalytic cycles to form C–C bonds with aryl bromides, alkynes and alkyl bromides.

Bibliographical metadata

Original languageEnglish
JournalChemical Science
Issue number33
Early online date27 Jun 2019
DOIs
Publication statusPublished - 2019