A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and functionCitation formats

  • External authors:
  • Stefan Baumgartner
  • J. Troy Littleton
  • Kendal Broadie
  • Manzoor A. Bhat
  • Ruth Harbecke
  • Judith A. Lengyel
  • Ruth Chiquet-Ehrismann
  • Hugo J. Bellen

Standard

A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. / Baumgartner, Stefan; Littleton, J. Troy; Broadie, Kendal; Bhat, Manzoor A.; Harbecke, Ruth; Lengyel, Judith A.; Chiquet-Ehrismann, Ruth; Prokop, Andreas; Bellen, Hugo J.

In: Cell, Vol. 87, No. 6, 13.12.1996, p. 1059-1068.

Research output: Contribution to journalArticle

Harvard

Baumgartner, S, Littleton, JT, Broadie, K, Bhat, MA, Harbecke, R, Lengyel, JA, Chiquet-Ehrismann, R, Prokop, A & Bellen, HJ 1996, 'A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function', Cell, vol. 87, no. 6, pp. 1059-1068. https://doi.org/10.1016/S0092-8674(00)81800-0

APA

Baumgartner, S., Littleton, J. T., Broadie, K., Bhat, M. A., Harbecke, R., Lengyel, J. A., ... Bellen, H. J. (1996). A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell, 87(6), 1059-1068. https://doi.org/10.1016/S0092-8674(00)81800-0

Vancouver

Baumgartner S, Littleton JT, Broadie K, Bhat MA, Harbecke R, Lengyel JA et al. A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell. 1996 Dec 13;87(6):1059-1068. https://doi.org/10.1016/S0092-8674(00)81800-0

Author

Baumgartner, Stefan ; Littleton, J. Troy ; Broadie, Kendal ; Bhat, Manzoor A. ; Harbecke, Ruth ; Lengyel, Judith A. ; Chiquet-Ehrismann, Ruth ; Prokop, Andreas ; Bellen, Hugo J. / A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. In: Cell. 1996 ; Vol. 87, No. 6. pp. 1059-1068.

Bibtex

@article{36b93a8e22eb4af1ba5dc730869c45f0,
title = "A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function",
abstract = "Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein with a cytoplasmic domain homologous to glycophorin C, a protein required for anchoring protein 4.1 in the red blood cell. Absence of NRX results in mislocalization of Coracle, a Drosophila protein 4.1 homolog, at SJs and causes dorsal closure defects similar to those observed in coracle mutants, nrx mutant embryos are paralyzed, and electrophysiological studies indicate that the lack of NRX in glial-glial SJs causes a breakdown of the blood-brain barrier. Electron microscopy demonstrates that nrx mutants lack the ladder-like intercellular septa characteristic of pleated SJs (pSJs). These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers.",
author = "Stefan Baumgartner and Littleton, {J. Troy} and Kendal Broadie and Bhat, {Manzoor A.} and Ruth Harbecke and Lengyel, {Judith A.} and Ruth Chiquet-Ehrismann and Andreas Prokop and Bellen, {Hugo J.}",
year = "1996",
month = "12",
day = "13",
doi = "10.1016/S0092-8674(00)81800-0",
language = "English",
volume = "87",
pages = "1059--1068",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function

AU - Baumgartner, Stefan

AU - Littleton, J. Troy

AU - Broadie, Kendal

AU - Bhat, Manzoor A.

AU - Harbecke, Ruth

AU - Lengyel, Judith A.

AU - Chiquet-Ehrismann, Ruth

AU - Prokop, Andreas

AU - Bellen, Hugo J.

PY - 1996/12/13

Y1 - 1996/12/13

N2 - Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein with a cytoplasmic domain homologous to glycophorin C, a protein required for anchoring protein 4.1 in the red blood cell. Absence of NRX results in mislocalization of Coracle, a Drosophila protein 4.1 homolog, at SJs and causes dorsal closure defects similar to those observed in coracle mutants, nrx mutant embryos are paralyzed, and electrophysiological studies indicate that the lack of NRX in glial-glial SJs causes a breakdown of the blood-brain barrier. Electron microscopy demonstrates that nrx mutants lack the ladder-like intercellular septa characteristic of pleated SJs (pSJs). These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers.

AB - Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein with a cytoplasmic domain homologous to glycophorin C, a protein required for anchoring protein 4.1 in the red blood cell. Absence of NRX results in mislocalization of Coracle, a Drosophila protein 4.1 homolog, at SJs and causes dorsal closure defects similar to those observed in coracle mutants, nrx mutant embryos are paralyzed, and electrophysiological studies indicate that the lack of NRX in glial-glial SJs causes a breakdown of the blood-brain barrier. Electron microscopy demonstrates that nrx mutants lack the ladder-like intercellular septa characteristic of pleated SJs (pSJs). These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers.

U2 - 10.1016/S0092-8674(00)81800-0

DO - 10.1016/S0092-8674(00)81800-0

M3 - Article

C2 - 8978610

VL - 87

SP - 1059

EP - 1068

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -