A Direct Arylation-Cyclization Reaction for the Construction of Medium-Sized Rings

Research output: Contribution to journalArticle

  • Authors:
  • Daniel Whitaker
  • Maria Batuecas
  • Paulo Ricci
  • Igor Larrosa


A strategy for assembling biaryls linked via a medium-sized ring is herein presented. π-Complexation of fluoroarenes to chromium tricarbonyl activates the molecule towards both C-H activation and nucleophilic aromatic substitution without covalently altering the molecular connectivity of the arene. The construction of bridged biaryl molecules with 6-10 membered core rings is achieved via a one-pot C-H arylation/nucleophilic aromatic substitution sequence. The methodology is applicable to the synthesis of heterocyclic as well as fully carbocyclic rings.

Bibliographical metadata

Original languageEnglish
JournalChemistry: A European Journal
Early online date31 Jul 2017
Publication statusPublished - 2017