A Blueprint for the Synthesis and Characterisation of Thin Graphene Oxide with Controlled Lateral Dimensions for BiomedicineCitation formats

  • External authors:
  • Leon Newman
  • Maria De Les Neus Lozano Valdes
  • Sourav P. Mukherjee
  • Bengt Fadeel

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A Blueprint for the Synthesis and Characterisation of Thin Graphene Oxide with Controlled Lateral Dimensions for Biomedicine. / Rodrigues, Artur; Newman, Leon; Lozano Valdes, Maria De Les Neus; Mukherjee, Sourav P.; Fadeel, Bengt; Bussy, Cyrill (Corresponding); Kostarelos, Kostas (Corresponding).

In: 2 D Materials, Vol. 5, No. 3, 11.05.2018.

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Rodrigues, Artur ; Newman, Leon ; Lozano Valdes, Maria De Les Neus ; Mukherjee, Sourav P. ; Fadeel, Bengt ; Bussy, Cyrill ; Kostarelos, Kostas. / A Blueprint for the Synthesis and Characterisation of Thin Graphene Oxide with Controlled Lateral Dimensions for Biomedicine. In: 2 D Materials. 2018 ; Vol. 5, No. 3.

Bibtex

@article{0fcc494cdaff47788d06c8807736774a,
title = "A Blueprint for the Synthesis and Characterisation of Thin Graphene Oxide with Controlled Lateral Dimensions for Biomedicine",
abstract = "Graphene-based materials (GBMs) have ignited a revolution in material science and technology, with electronic, optical and mechanical properties that are of relevant interest for a wide range of applications. To support the development of these enabling technologies, a global research effort has been invested to assess their hazard and biocompatibility. Different production methods have however generated a diverse collection of GBMs with different physicochemical properties, leading to a variety of biological outcomes that are still not fully understood. To better understand the biological interactions of GBMs with biological systems and allow the design of safer materials, a thorough physicochemical characterisation is therefore highly recommended. The aim of the present work was to produce a blueprint for the synthesis and characterisation of non-pyrogenic graphene oxide (GO) flakes with three different controlled lateral dimensions, which could be further used for either hazard assessment or biomedical proof-of-concept studies. A battery of techniques used to characterise the physicochemical properties of the GO samples included atomic force microscopy, transmission electron microscopy, Fourier-transformed infra-red spectroscopy, X-ray photoelectron spectroscopy and Raman spectroscopy. The combination of these different techniques confirmed that only the lateral dimension varied among the GO materials produced, without significant change in any other of their fundamental physicochemical properties, such as the thickness or surface chemistry. The proposed systematic approach in GO batch production for biology will hopefully contribute to a better understanding of the material properties that govern their interactions with biological systems and offer a blueprint towards standardisation of biologically relevant 2D materials.",
keywords = "graphene, production , characterisation, biology, medicine, biomedical",
author = "Artur Rodrigues and Leon Newman and {Lozano Valdes}, {Maria De Les Neus} and Mukherjee, {Sourav P.} and Bengt Fadeel and Cyrill Bussy and Kostas Kostarelos",
year = "2018",
month = "5",
day = "11",
doi = "10.1088/2053-1583/aac05c",
language = "English",
volume = "5",
journal = "2 D Materials",
issn = "2053-1583",
publisher = "IOP Publishing Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - A Blueprint for the Synthesis and Characterisation of Thin Graphene Oxide with Controlled Lateral Dimensions for Biomedicine

AU - Rodrigues, Artur

AU - Newman, Leon

AU - Lozano Valdes, Maria De Les Neus

AU - Mukherjee, Sourav P.

AU - Fadeel, Bengt

A2 - Bussy, Cyrill

A2 - Kostarelos, Kostas

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Graphene-based materials (GBMs) have ignited a revolution in material science and technology, with electronic, optical and mechanical properties that are of relevant interest for a wide range of applications. To support the development of these enabling technologies, a global research effort has been invested to assess their hazard and biocompatibility. Different production methods have however generated a diverse collection of GBMs with different physicochemical properties, leading to a variety of biological outcomes that are still not fully understood. To better understand the biological interactions of GBMs with biological systems and allow the design of safer materials, a thorough physicochemical characterisation is therefore highly recommended. The aim of the present work was to produce a blueprint for the synthesis and characterisation of non-pyrogenic graphene oxide (GO) flakes with three different controlled lateral dimensions, which could be further used for either hazard assessment or biomedical proof-of-concept studies. A battery of techniques used to characterise the physicochemical properties of the GO samples included atomic force microscopy, transmission electron microscopy, Fourier-transformed infra-red spectroscopy, X-ray photoelectron spectroscopy and Raman spectroscopy. The combination of these different techniques confirmed that only the lateral dimension varied among the GO materials produced, without significant change in any other of their fundamental physicochemical properties, such as the thickness or surface chemistry. The proposed systematic approach in GO batch production for biology will hopefully contribute to a better understanding of the material properties that govern their interactions with biological systems and offer a blueprint towards standardisation of biologically relevant 2D materials.

AB - Graphene-based materials (GBMs) have ignited a revolution in material science and technology, with electronic, optical and mechanical properties that are of relevant interest for a wide range of applications. To support the development of these enabling technologies, a global research effort has been invested to assess their hazard and biocompatibility. Different production methods have however generated a diverse collection of GBMs with different physicochemical properties, leading to a variety of biological outcomes that are still not fully understood. To better understand the biological interactions of GBMs with biological systems and allow the design of safer materials, a thorough physicochemical characterisation is therefore highly recommended. The aim of the present work was to produce a blueprint for the synthesis and characterisation of non-pyrogenic graphene oxide (GO) flakes with three different controlled lateral dimensions, which could be further used for either hazard assessment or biomedical proof-of-concept studies. A battery of techniques used to characterise the physicochemical properties of the GO samples included atomic force microscopy, transmission electron microscopy, Fourier-transformed infra-red spectroscopy, X-ray photoelectron spectroscopy and Raman spectroscopy. The combination of these different techniques confirmed that only the lateral dimension varied among the GO materials produced, without significant change in any other of their fundamental physicochemical properties, such as the thickness or surface chemistry. The proposed systematic approach in GO batch production for biology will hopefully contribute to a better understanding of the material properties that govern their interactions with biological systems and offer a blueprint towards standardisation of biologically relevant 2D materials.

KW - graphene

KW - production

KW - characterisation

KW - biology

KW - medicine

KW - biomedical

U2 - 10.1088/2053-1583/aac05c

DO - 10.1088/2053-1583/aac05c

M3 - Article

VL - 5

JO - 2 D Materials

JF - 2 D Materials

SN - 2053-1583

IS - 3

ER -