A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Abstract

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space-time yield of 2 g L-1 d-1.

Bibliographical metadata

Original languageEnglish
Pages (from-to)9790-9793
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number46
Early online date10 Nov 2017
DOIs
Publication statusPublished - 14 Dec 2017