Understanding the Therapeutic Potential of Interleukin-1 Inhibition in Intracerebral Haemorrhage.

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Research Project Agreement [RPA]


Inflammation worsens brain damage after bleeding into the brain. Interleukin-1 is a messenger molecule driving this damage. IL1-Ra is a licenced drug that blocks interleukin-1 and may improve recovery from brain haemorrhage. We will measure interleukin-1 levels in the brain after haemorrhage using samples from an ongoing surgical clinical trial. We will test how easily IL-1Ra might enter the brain after brain haemorrhage using advanced scans. These first two studies will help decide the best dose of IL-1Ra and how long we need to give it for. We will then test whether IL-1Ra reduces brain swelling in intracerebral haemorrhage patients.
Short titleR:KBA Interleukin-1
Effective start/end date1/03/1529/02/20

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