Biography

Richard Bryce heads up the computational-aided drug design group in the School of Pharmacy.  He is a Reader in Biomedicinal Chemistry, having read chemistry at St. Andrews University (BSc, 1995) and computational chemistry at Manchester University (PhD, 1998).  He was a Robert Lincoln MacNeil scholar at the University of Pennsylvania (1992-1993) and a Ramsay Memorial Fellow at the University of Manchester (1999-2001).  His work receives support from a variety of sources, including EPSRC, The Wellcome Trust, MRC, BBSRC and the Royal Society.  He is a fellow of the Royal Society of Chemistry and chair of the Molecular Graphics and Modelling Society.

Qualifications

  • 2005 - FRSC CChem
  • 1998 - MRSC CChem
  • 1998 - PhD(University of Manchester)
  • 1995 - BSc(University of St Andrews)

Research interests

The work in Richard Bryce's group is aimed at developing computational models to improve the accuracy with which molecular processes are described and understood in the condensed phase and then to integrate and employ these methods in the drug design and development process, involving collaboration with medicinal chemists, biochemists and biologists.

His research interests involve the development and application of accurate and efficient computational methods for structure-based drug design.  A major focus of his work is the theoretical investigation of carbohydrate structure, energetics, dynamics and reactivity.  This requires accurate treatment of aqueous solvent, which as led to the development and application of solvent models to carbohydrate analogue systems.  The group employs a variety of computational techniques, including molecular simulation and hybrid quantum mechanical (QM)/molecular mechanical (MM) models

Research profile

Teaching

  • Physics of Intermolecular Forces, Protein-Ligand Interactions, Computational Aspects of Rational Drug Design (Molecular Simulation, De Novo Design, Docking, Virtual Screening, QSAR)

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