Biography

Jacky graduated in Medicine from Manchester University in 1992 and continued her training around the North West region in General and Respiratory Medicine. She only undertook research in her final year of specialist registrar training, taking time out to study for a PhD in the 'Measurement of Cough', awarded in 2004. This involved close collaboration with computer scientists and fuelled an interest in acoustics and signal processing. After completing specialist training she returned to research and was funded by a Stepping Stones Award from Manchester University and  an MRC Clinician Scientists Fellowship Award until 2012.

In collaboration with Mr Kevin McGuinness (Clinical engineer) she has developed a novel method for automated cough detection. She is an inventor on a patent owned by the University Hospital of South Manchester, covering novel concepts for automated detection of cough from sound signals. This patent is the subject of a license agreement with a medical device company (Vitalograph) with whom she collaborates.

Whilst she continues to work on developing other endpoints in cough monitoring, her main research interests are in the translation of mechanisms of underlying cough reflex hypersensitivity and the testing of novel anti-tussive therapies.

Information about the cough clinic and clinical research can be found at www.combatmycough.com

Collaborators and affiliated staff

Affiliated Staff

Clinical Team

  • Dr Angela Kelsall (Post doctoral Pulmonary Physiologist)
  • Dr Imran Satia (Clinical Fellow)
  • Dr Huda Badri (Clinical Fellow)
  • Ms Kimberly Holt (Research Assistant)
  • Ms Rachel Dockry (Research Assisstant)
  • Ms Carmen Gibbard (Research Assisstant)
  • Ms Kitty Ahern (Research Technician)
  • Mrs Shilpi Sen (Research Technician)
  • Mr Phil Turner (Research Techician)
  • Mr Paul Czyzyk (Research Technician)

Engineering Team

  • Dr Kevin McGuinness (Senior Clinical Engineer)
  • Mr Zbigniew Koziel (Research Assistant)

Academic Collaborators

  • Prof Maria Belvisi, National Heart and Lung Institute, Imperial College, London
  • Dr Brendan Canning, Johns Hopkins Medical Institutions, Balitmore, Maryland
  • Prof Doug Corfield, University of Manchester
  • Mr Andy Camilleri, ENT Surgery, UHSM
  • Mr Simon Galloway, GI Surgery, UHSM
  • Professor Peter Calverley and Dr John Earis, University Hospital Aintree, University of Liverpool
  • Professor Neil Thomson, Division of Immunology, Infection & Inflammation, University of Glasgow
  • Prof Jeff Pearson and Dr Chris Ward, School of Clinical Medical Sciences, Newcastle University
  • Dr Andrea Aliverti, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy

Memberships of committees and professional bodies

  • Member of the Royal College Physicians (London)
  • Member of British Thoracic Society
  • Member European Respiratory Society
  • Member of American Thoracic Soceity
  • Member of the European Task Force for the Assessment of Cough
  • ACCP guideline committee for the Management and Diagnosis of Chronic Cough
  • Member of the International Society for the Study of Cough

Methodological knowledge

Clinical research skills: bronchial challenge testing, cough reflex sensitivity testing, pulmonary function testing, exhaled nitric oxide measurement, sputum induction, endo-bronchial biopsy, brushing and lavage, optico-electronic plethysmography, intra-oesophageal and gastric balloon pressure measurements

Clinical trials experience: design, applying for ethical approval, patient recruitment, data collection and analysis, including clinical trials of investigational medicinal products for the treatment of cough.

Statistics and data analysis skills: I have an interest in advanced statistical techniques such as factor analysis, cluster analysis and recently structural equation modelling.

Signal Processing Skills: I have a basic understanding of acoustic signal processing and speech recognition techniques from a close collaboration with computer scientists and engineers

Overview

Jacky Smith is a Professor of Respiratory Medicine at the University of Manchester and an Honorary Consultant at the University Hospital of South Manchester NHS Foundation Trust. She runs a multi-disciplinary research team whose focus is on understanding mechanisms underlying pathological cough and a regional clinical service seeing patients with refractory chronic cough. She is also the Director of the NIHR South Manchester Respiratory and Allergy Clinical Research Facility and Specialty Lead for Respiratory in the Greater Manchester Clinical Research Network.

Qualifications

MB ChB Manchester 1992

MRCP London 1996

PhD Manchester 2004

Research interests

Research interests include:

  • Measurement of cough and the cough reflex
  • Airway Innervation and mechanisms of neuronal sensitisation
  • Clinical trials of novel anti-tussive agents
  • The role of gastro-oesophageal reflux in chronic cough

Research profile

Teaching

  • Academic advisor to undergraduate medical students
  • Advisor to Academic Clinical Fellows
  • Supervisor to an Academic Clinical Fellow
  • Mentor to NIHR Clinician Scientist

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