Research areas

  • R Medicine (General) - Rheumatology, Myositis, Muscle, Antibodies

Biography

Dr Hector Chinoy is a Senior Clinical Lecturer in Rheumatology at The University of Manchester, UK, where he conducts an active programme of research, is the Clinical Rheumatology MSc Programme Director, and is also an Honorary Consultant Rheumatologist at Salford Royal Hospital.

Dr Chinoy completed his medical degree at the University of Nottingham in 1996 and completed an Arthritis Research UK PhD fellowship at The University of Manchester. He has research interests in genetic, epidemiological and clinical aspects of adult idiopathic inflammatory myopathy, as well as immunogenicity of biologic therapy, and supervises a number of PhD and Masters students. He is principal investigator of a UK Medical Research Council funded prospective myositis cohort collection called MYOPROSP. At Salford Royal, he runs general rheumatology, adult neuromuscular and combined psoriasis/psoriatic clinics.

He is a reviewer for several major rheumatology peer-reviewed journals, advisory editor for Arthritis and Rheumatology, on the editorial board for the European Medical Journal and Reumatologia, and is on the abstract selection committee for the British Society for Rheumatology, European League Against Rheumatism and American College of Rheumatology annual conferences.

He is co-chair of UKMYONET, a national consortium that fosters collaborative research in inflammatory myopathy, chair of the Euromyositis registry, a consortium that collects standardised clinical data in over 30 countries, and is a member of the Arthritis Research UK Autoimmune Rheumatic Disease Clinical Trials Subcommittee.

Collaborators and affiliated staff

  • Prof R.G.Cooper, Consultant Rheumatologist, Salford Royal NHS Foundation Trust
  • Prof W.E.Ollier, Professor of Immunogenetics/Director, CIGMR
  • Dr J.Lamb, Lecturer in Complex Human Genetics/Genomics, CIGMR
  • Prof L.R.Wedderburn, Professor in Paediatric Rheumatology, Institute of Child Health, UCL, London
  • Prof N.J.McHugh, Consultant Rheumatologist, RNHRD, Bath. Hon Professor University of Bath

Memberships of committees and professional bodies

  • British Society for Rheumatology
  • American College of Rheumatology
  • General Medical Council
  • British Medical Association
  • Royal College of Physicians (London)

Overview

Senior Lecturer in Rheumatology, based in the Musculoskeletal Group, Institue of Inflammation and Repair. Also Honorary Clinical Consultant at The Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust. The academic component of my job is HEFCE funded and the clinical component funded by the trust, the split being 50:50.

My primary research interest is in the investigation of genetic and environmental risk factors in inflammatory muscle disease, or myositis. This is complemented via the Salford Royal Adult Neuromuscular clinic, where patients are clinically managed within an NHS Specialised Rheumatology service and are recruited into ongoing research studies.

Qualifications

  • 2007 PhD, Medicine (The University of Manchester)
  • 2004 MSc, Clinical Rheumatology (The University of Manchester)
  • 2000 MRCP (UK)
  • 1996 B.M., B.S. (University of Nottingham)
  • 1994 B.Med.Sci (Hons), 2nd class, division 1 (University of Nottingham)

Research interests

My current research interest is in the immunogenetics of idiopathic inflammatory myopathy (IIM).

Objectives:

  • Further analysis of GWAS and Immunochip data generated from a UK-based and international cohort of IIM patients.
  • To facilitate and oversee replication association studies of disease susceptibility signals from GWAS and pan-autoimmune loci
  • To facilitate and oversee the identification of potential disease-causal variants within IIM susceptibility genes via genetic re-sequencing and high-throughput genotyping.
  • Coordinating a prospective collection of IIM data in the UK (MYOPROSP)
  • NHS England registry collection of IIM patients commencing rituximab (MYOACT)
  • Novel imaging modalities in IIM
  • Use of PROMS to measure disease activity in IIM
  • Dissemination of Euromyositis, a European-wide standardised web-based IIM database facility (collaboration)
  • To study subclinical atherosclerosis and endothelial dysfunction in IIM
  • To facilitate collection of blood and tissue as part of a muscle biobank and UKMYONET, a nationwide UK Clinical Research Network IIM study
  • To investigate the interaction of smoking and HLA-DRB1*03 for the development of myositis antibodies in IIM (collaboration)
  • To assist in the clinical and genetic phenotypic characterisation of IIM cases with novel autoantibody profiles (collaboration)
  • Management of idiopathic inflammatory myopathies: adult patients and professional specialists’ perspectives on current care in the UK (collaboration)

Teaching

A) University

Postgraduate Teaching

  • MSc Clinical Rheumatology Programme, The University of Manchester
  • Programme director (350 Teaching Load hours, ~ 1 PA/week)
  • Teaching and examining role in the programme
  • Supervision of students in written dissertation component (1 current, 3 previous).

 Undergraduate Work

  • Teaching:  4th year medical students as part of ward/ clinical-based sessions, expert patient sessions and formal rheumatology lectures (Hospital-based) (2009-present)
  • Advisor: Phase II Academic Advisor (2015-present)
  • Examiner: Lead and examiner for Mind and Movement OSCE examination Salford Royal (commitment 5 days per year) (Hospital-based) (2013-present)
  • Supervisor: Year 3/4 APEP medical students
  • Interviews: Manchester Medical School 2015 applicants, 15/12/2014, 15/01/2015

B) Other roles

  • British Society for Rheumatology (BSR) representation - chair of the BSR myositis special interest group
  • Arthritis Research UK Representative, Autoimmune Rheumatic Disease Clinical Trials Subcommittee (2012-present)
  • NHS Specialist Commissioning: Co-drafting NHS England national policy for the use of rituximab in myositis (2014)
  • Arthritis and Rheumatology, Advisory Editor, (11/2014-)
  • Reviewer for multiple journals (eg ARD, Arthritis Rheum, Arthritis Care & Research, Rheumatology, Clin Exp Rheumatol)
  • Joint lead of UKMYONET, a UK-wide research group to promote collaborative research in myositis
  • Member, EuMyoNet & MYOGEN, international consortia collaborating in myositis research
  • Chair, Euromyositis Registry, a web-based database consortium of over 20 countries
  • Invited speaker for national and international conferences (examples ACR 2012, EULAR 2014, 1st National Chinese Myositis Conference,China-Japan Friendship Hospital, Beijing) 

ID: 621862