Professor Evans has established a national and international reputation in clinical and research aspects of cancer genetics, particularly in neurofibromatosis and breast cancer. He has developed a clinical service for cancer genetics in the North West Region of England, which is nationally regarded. He is an important opinion leader nationally through membership of committees and was chairman of the NICE Familial Breast Cancer Guideline Development Group (2002-2010) and is now clinical lead (2011-). He lectures throughout the UK and internationally on hereditary breast cancer and cancer syndromes. He has given plenary lectures at many international meetings including the International Congress of Human Genetics and two invited lecture tours across Australia (1995, 2001). He has developed a national training program for clinicians, nurses and genetic counsellors in breast cancer genetics and established a system for risk assessment and counselling for breast cancer in Calman breast units implemented through a training course (1998-2011).
He has published 628 peer reviewed research publications; 240 as first or senior author. He has published over 90 reviews and chapters and has had a book published by Oxford University Press on familial cancer. He has an ISI web of knowledge H-index of 86 and a google scholar H-index of 113 having only published his first article in 1990. In the last 5 years he has raised over £10 million in grants for multicentre and local studies – approximately £5 million to Manchester. He is Chief Investigator on a £1.59 million NIHR program grant (2009-2014 and 2016-2020) on breast cancer risk prediction and also has an NIHR RfPB grant as CI (2011). He has led a successful bid for a Nationally funded NF2 service (£7.5 million pa) that started in 2010 and is involved in the national complex NF1 service.
Dr Miriam Smith
Dr Elaine Harkness
Prof William Newman
Prof Tony Howell
Member and Ex Council Member of the Clinical Genetics Society
Member and Ex Chairman of the Cancer Genetics Group
Member and ex Council Member of the British Society of Genomic Medicine
Member European Society of Human Genetics
Professor of Medical Genetics and Cancer Epidemiology, The University of Manchester
Consultant in Medical Genetics and Cancer Epidemiology, Central Manchester Hospitals NHS Foundation Trust and The Christie NHS Foundation Trust
MB BS MRCP MD FRCP
The main focus of research has been on genetic predisposition to breast cancer and type 2 neurofibromatosis. I have developed a national clinical and molecular database for NF2 which has become an invaluable research tool being the largest such database worldwide. We have also collected the largest number of breast cancer families UK wide which has meant we are the biggest contributor to a number of national breast cancer research initiatives (FBOC, EMBRACE, MARIBS, IMPACT). The focus of my research is moving away from clinical pattern recognition and gene identification towards cancer prevention. With Professor Howell we are setting up a major programme for breast cancer prevention in Manchester. This involves development of surrogate markers. As our clinical work has provided the largest number of families with known high risk breast cancer gene defects we are likely to lead prevention strategies in the UK from now on. Use of high tech MRI will also allow the proper assessment of non-surgical intervention in the treatment of benign brain tumours, with work in collaboration with Professor Jackson.
Director Nannerch Players
Trustee Breast Cancer Now
Trustee Neuro Foundation
Trustee Hereditary Breast Cancer HelplineAdvisor The Gorlin Group Scientific Advisor Genesis Breast Cancer Prevention Appeal
1. a) Medical student clinical course teaching (full year seminars). Medical student options two per year, 3 in 1995.
b) MSc in genetic counselling
c) teaching of registrar/SR grades internally + lectures to SHO and registrars in paediatrics and obstetrics.
d) Postgraduate lectures throughout region.
e) Postgraduate education representative of department.
2. a) FRCR in clinical oncology seminars - Christie hospital
b) MSc in medical oncology seminars - Christie hospital
c) MSc in cancer genetics - Royal Marsden hospital.
3. Devised and supervise Breast Cancer Genetics Training course for breast care nurses and clinicians. Approved by Director of Cancer Services (Region) and School of Nursing.