After spending 10 years in contract research, responsible for metabolism and pharmacokinetic studies for regulatory submission by major international companies, David studied for his PhD at Manchester (with Pr. Brian Houston) and subsequently became a Research Fellow within the Centre for Applied Pharmacokinetic Research.

Collaborators and affiliated staff

This research is part of the remit of the Centre for Applied Pharmacokinetic Research, within the School, which involves a consortium of five major pharmaceutical companies. Internal collaboration is primarily with Professor Brian Houston.

Memberships of committees and professional bodies

Royal Society of Chemistry

Royal Society of Biology

International Society for the Study of Xenobiotics

Methodological knowledge

David is responsible for the analytical chemistry facility within the Centre for Applied Pharmacokinetic Research, which provides capability for drug quantitation by liquid chromatography-mass spectrometry for experimental researchers (with three triple-quadrupole intruments).


Bsc, PhD

Research interests

Prediction of drug metabolic clearance is a cornerstone of successful drug discovery and development. The predictive system framework comprises an in vitro component (human liver cells or isolated enzymes) and an extrapolation model (In vitro-in vivo) component. A generic system, capable of reliable quantitative prediction, remains an important goal and will depend on continued development of all aspects of the system.

Mechanistic principles are key to this development and interest has focussed on drug kinetics in vitro - particularly the critical role of nonspecific binding of drugs and the uptake of drugs into hepatocytes - and the incorporation of these complexities into prediction models.

Current research focusses on understanding the sources of variability (human and experimental) which complicate the use and evaluation of predictive systems.

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