Supporting Nanobiotix development of NBTXR3, the world’s first nanomedicine to reach market.

Impact: Health impacts

Narrative

Currell’s local effect modelling approach showed a deep analogy between mechanisms of heavy-ion and nanoparticle enhanced therapy, providing a simple framework to predict the physical component of dose enhancement due to nanoparticles [1] which we have extended to provide the first account for clinically relevant clusters of nanoparticles [2]. The de-facto standard for predicting the efficacy of nanoparticles irradiated in tumours, with many publications using the method or variants of it, it allows computational prediction of efficacy of radiation nanomedicines.

References
1. Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles, Nature Scientific Reports, 1, 18; DOI:10.1038/srep00018 (2011).
2. Physical Radiation Enhancement Effects Around Clinically Relevant Clusters of Nanoagents in Biological Systems, Nature Scientific Reports, 9, 8156 DOI: 10.1038/s41598-019-44482-y

Category of impact

  • Health impacts
Date
20 Jun 2011 - 28 Jan 2020