Opening the door to ligand-based drug discovery: a rapid and accurate technology for determining bioactive 3D molecular shapes

Impact: Economic impacts, Health impacts, Technological impacts

Publications

  1. 2013
  2. Published

    Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation

    Blundell, C. D., Packer, M. J. & Almond, A., 1 Sep 2013, In: Bioorganic and Medicinal Chemistry. 21, 17, p. 4976-4987 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2006
  4. Published

    Complete assignment of hyaluronan oligosaccharides up to hexasaccharides

    Blundell, C. D., Reed, M. A. C. & Almond, A., 11 Dec 2006, In: Carbohydrate Research. 341, 17, p. 2803-2815 12 p.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Enzymatic and chemical methods for the generation of pure hyaluronan oligosaccharides with both odd and even numbers of monosaccharide units

    Blundell, C. D. & Almond, A., 15 Jun 2006, In: Analytical Biochemistry. 353, 2, p. 236-247 11 p.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Hyaluronan: The absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models

    Blundell, C. D., DeAngelis, P. L. & Almond, A., 15 Jun 2006, In: Biochemical Journal. 396, 3, p. 487-498 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix

    Almond, A., DeAngelis, P. L. & Blundell, C. D., 19 May 2006, In: Journal of molecular biology. 358, 5, p. 1256-1269 13 p.

    Research output: Contribution to journalArticlepeer-review

  8. 2005
  9. Published

    Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation

    Almond, A., DeAngelis, P. L. & Blundell, C. D., 2 Feb 2005, In: Journal of the American Chemical Society. 127, 4, p. 1086-1087 1 p.

    Research output: Contribution to journalArticlepeer-review

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