Accurate in vitro prediction of in vivo genotoxicity and cancer hazard; reducing costs to industry and the use of animals in research

Impact: Economic impacts, Health impacts, Technological impacts

Publications

  1. 2015
  2. Published

    Ames positive boronic acids are not all eukaryotic genotoxins

    Walmsley, R. & Scott, H., 2015, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 777, 1, p. 68-72 4 p.

    Research output: Contribution to journalArticle

  3. 2012
  4. Published

    Development of a high-throughput gaussia luciferase reporter assay for the activation of the GADD45a gene by mutagens, promutagens, clastogens, and aneugens

    Hughes, C., Rabinowitz, A., Tate, M., Birrell, L., Allsup, J., Billinton, N. & Walmsley, R. M., Dec 2012, In : Journal of Biomolecular Screening. 17, 10, p. 1302-1315 13 p.

    Research output: Contribution to journalArticle

  5. Published

    Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay

    Topham, C. H., Billinton, N. & Walmsley, R. M., Jul 2012, In : Toxicological Sciences. 128, 1, p. 79-91 12 p.

    Research output: Contribution to journalArticle

  6. 2010
  7. Published

    GADD45a-GFP GreenScreen HC assay results for the ECVAM recommended lists of genotoxic and non-genotoxic chemicals for assessment of new genotoxicity tests

    Birrell, L., Cahill, P., Hughes, C., Tate, M. & Walmsley, R. M., 2010, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 695, 1-2, p. 87-95 8 p.

    Research output: Contribution to journalArticle

  8. 2009
  9. Published

    Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay

    Jagger, C., Tate, M., Cahill, P. A., Hughes, C., Knight, A. W., Billinton, N. & Walmsley, R. M., Jan 2009, In : Mutagenesis. 24, 1, p. 35-50 15 p.

    Research output: Contribution to journalArticle

  10. 2008
  11. Published

    Interlaboratory assessment of the GreenScreen HC GADD45a-GFP genotoxicity screening assay: An enabling study for independent validation as an alternative method

    Billinton, N., Hastwell, P. W., Beerens, D., Birrell, L., Ellis, P., Maskell, S., Webster, T. W., Windebank, S., Woestenborghs, F., Lynch, A. M., Scott, A. D., Tweats, D. J., van Gompel, J., Rees, R. W. & Walmsley, R. M., 31 May 2008, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 653, 1-2, p. 23-33 10 p.

    Research output: Contribution to journalArticle

  12. 1997
  13. Published

    Green fluorescent protein as a reporter for the DNA damage-induced gene RAD54 in Saccharomyces cerevisiae

    Walmsley, R. M., Billinton, N. & Heyer, W. D., Dec 1997, In : Yeast. 13, 16, p. 1535-1545 10 p.

    Research output: Contribution to journalArticle

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