The strong interdisciplinary focus and mode of operation in the Manchester Institute of Biotechnology (MIB) enables our scientists and engineers to drive state-of-the-art biotechnology research through establishing new types of collaboration. The MIB’s approach is pluralistic, integrative and non-exclusive functioning flexibly as a partner to researchers across a broad spectrum of disciplines which are fluid and constantly evolving. Using advanced quantitative methods to explore the relationship between the macro behaviour of biological systems and the properties of their nanoscale components we see this understanding as a basis for developing new biotechnologies that will find applications in areas such as human health, the energy economy, food security, industrial transformations and the environment. A defining feature of our mission is the incorporation of rigorous, cutting-edge principles and technologies derived from the physical sciences, engineering, mathematics and computation into novel approaches to elucidating the molecular mechanisms that underpin living processes and systems. An extensive programme of technology development lies at the heart of our research programmes, driven by expertise from the quantitative sciences and engineering, allowing us to accelerate progress through the implementation of state-of-the-art enabling technologies.