Proteomic Quantification of Human Blood-Brain Barrier Drug Transporters and Solute Carriers in Healthy Individuals and Dementia Patients

Activity: Talk or presentationOral presentation

Description

The Blood-Brain Barrier (BBB) maintains brain homeostasis by controlling traffic of molecules from the circulation. This function is predominantly dependent on proteins expressed at the BBB, mainly transporters and tight junction proteins. Alterations to BBB proteins can lead to changes in brain function affecting the susceptibility of the central nervous system to exposure to xenobiotics in the systemic circulation. Recent advances in quantitative proteomics can enable measurement of transporters in the BBB, and therefore can be used to develop pharmacokinetic models for psychoactive drugs.
30 Nov 2018

Event (Conference)

Title8TH Annual UK & Ireland Early Career Blood Brain Barrier Symposium
Period30/11/1830/11/18
Web address (URL)
LocationUniversity of Oxford
CityOxford
CountryUnited Kingdom
Degree of recognitionNational event