Mr Declan Creamer

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Overview

BBSRC PhD Student, Chris Grant Lab (2019-2023)

The majority of proteins must fold into their correct 3D structures in order to perform their biological functions. Under adverse conditions, proteins may become misfolded and accumulate into toxic aggregates. In order to maintain integrity of the proteome during stress, cells possess a vast network of chaperones and proteolytic systems which serve to counteract accumulation of misfolded proteins. This is mainly achieved via refolding, degradation or sequestration into non-toxic inclusions, and is an important mechanism to understand due to its association with neurodegenerative diseases and ageing.

My research aims to use a yeast model to understand the cellular responses to toxicity caused by protein misfolding and aggregation. A key focus will be to elucidate the role of the Ras/PKA pathway in mediating conditions which induce misfolding such as oxidative stress and heat shock.

External positions

Research Assistant, Zentrum für Molekulare Biologie der Universität Heidelberg

Sep 2017Aug 2018

Areas of expertise

Biology, Medicine and Health (BMH) Domains

Keywords

  • Protein Aggregation, Oxidative Stress, Protein kinase A, Protein quality control, Sequestration, Heat shock proteins, Protein folding

Education / academic qualifications

  • 2019 - Bachelor of Science, BSc (Hons) Biochemistry with a Modern Language (German), The University of Manchester

Related information

Publications

Research output: Contribution to journalArticlepeer-review

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Prizes

Prize: Prize (including medals and awards)

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