Dr Cyrill Bussy

Lecturer

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Overview

Research

We work at the interface of material sciences, biology, and physiopathology, using the most advanced methodologies in each area to reveal which physicochemical or biological features of nanomaterials are the most likely to induce inflammation, genotoxicity or toxic reactions, with the ultimate aim to guide the production of safer nanomaterials using a safer-by-design approach.

Using carbon nanomaterials, in particular graphene based and two-dimensional materials, as case study, we have shown that dimensions, surface properties such as surface chemistry, and the ability of nanomaterials to adsorb biological molecules (bio-corona) are three essential parameters that can be used to predict the toxicity or inertness of manufactured nanomaterials.

Teaching

  • Faculty of Biology Medicine and Health: MBChB, MPharm, UG biological sciences, MSc, MRes and CDT programmes
  • Faculty of Sciences and Engineering: MSc Biomaterials and CDT Graphene programmes 

University of Manchester Roles

Other Affiliations

Biography

Employment history

  • 2013 - present | Lecturer at the University of Manchester, Faculty of Biology, Medicine and Health
  • 2011 - 2013 | Marie Sklodowska-Curie career development Fellowship (EU-FP7, NanoNeuroHOP project) at UCL School of Pharmacy, University College London, UK. Project aiming to reveal the neuro safety profile of different carbon based materials, modified for biomedical applications.

  • 2010 - 2011 | Visiting Postdoctoral Research Associate at the Nanomedicine Lab, UCL School of Pharmacy, University College London, UK. Project aiming to assess the neuro safety profile of carbon nanotubes functionalised for biomedical applications. Project co-funded by French Government (Grenelle de l'Environment).
  • 2002 - 2005 | PhD research candidate/engineer at IRSN (Radiotoxicology and Radiobiology Lab) and IRBA (Institut de Recherche Biomédicale des Armées, former CRSSA, part of the French Defence Health Service), France. Project aiming to assess the neurotoxicity of radionucleides at environmental doses (project ENVIRHOM). This research was co-funded by the French Union Chamber of Mineral Waters (including Danone Group, Nestle Waters France, Neptune).

Qualifications

 

Social responsibility

Research with impact beyond academia:

  • Our review article on graphene published in 2013, titled: ‘Safety considerations for graphene: lessons learnt from carbon nanotubes’ is featured as a guide to help inform in a special thematic issue of Science for Environment Policy, a free news and information service published by the European Commission’s Directorate-General Environment, which provides the latest environmental policy-relevant research findings. More details here

Engaging our communities:

  • The CNRS (French National Center for Scientific Research) has released in its online journal for non-experts a special issue on graphene safety (2015), including informations based on an interview with Dr. Bussy (in French)
  • Research article on carbon nanotubes published in 2008, titled: ‘Carbon Nanotubes in Macrophages: Imaging and Chemical Analysis by X-ray Fluorescence Microscopy’ is featured in the European Synchrotron Radiation Facility ESRF Highlights public newsletter
  • Some of our experimental work on the interactions of carbon nanotubes with brain cells is amongst the finalists of the Wellcome Image Awards 2015, under the title “Delivering medicine to the brain” submitted by Dr. Al-Jamal. The FIB-cryo-SEM (Focused Ion Beam Scanning Electron Microscopy) image is of primary brain cell cultures prepared by Dr. Bussy at the Nanomedicine Lab, UCL School of Pharmacy led by Prof. Kostarelos (now relocated at the University of Manchester) and exposed to functionalised carbon nanotubes. The samples were imaged under a FEI Quanta 3D ESEM at the Queens’ Mary NanoVision Centre with the help of Kenneth Png (now applications specialist at Carl Zeiss NTS Ltd). This work was performed in collaboration with King’s College London (Dr. Al-Jamal), and the Neuroscience Institute at the National Research Centre (CNR) in Italy (Prof. Pizzorusso).You can read the full article related to this work here. The Wellcome Image Awards 2015 were on display across the UK and USA, including the  Science and Industry Museum in Manchester.

Memberships of committees and professional bodies

Areas of expertise

  • Q Science (General) - toxicology, materials, nanomaterials, biomaterials, biocompatibility, Biomedical Engineering, environmental health, graphene, carbon nanotubes, Hazards, safety assessment, material related inflammation

Keywords

  • Graphene, Toxicology, Nanomaterials, Biocompatibility, Environmental Health

Related information

Activities

Activity: Participating in or organising event(s)Participating in a conference, workshop, exhibition, performance, inquiry, course etc

Activity: Participating in or organising event(s)Participating in a conference, workshop, exhibition, performance, inquiry, course etc

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Prizes

Prize: Fellowship awarded competitively

Prize: National/international honour

Prize: National/international honour

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Impact

Impact: Health impacts, Societal impacts, Technological impacts, Political impacts, Environmental impacts

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