Dr Annalisa Tirella

Lecturer

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Overview

The BioEngineered Systems research group is highly multidisciplinary, the two main research interests are:

1) Formulate nano- and micro-systems encapsualting therapeutics for advanced drug delivery. Current research projects focus on: nanoparticles for targeted delivery to cancer cells (e.g. receptor mediated), nanoparticles for controlled drug release.

2) Design of 3D in vitro systems replicating physiological and pathological charcteristics. Current research projects focus on: biomaterials with controlled stiffness and composition to study cell-material interaction in cancer progression, 3D systems for the release of distinctive biochemicals e.g. protein.

The ultimate aim is to develop high-throughput in vitro systems able to replicate distinctive properties of tissues to better test drug delivery and therapeutic effects.

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Biography

Annalisa started her research for the design and manufacturing of in vitro models for tissue engineering and regenerative medicine since her bachelor thesis in Bioengineering at the University of Pisa, developing a microfluidic bioreactor for toxicology drug screening and designing 3D cell laden hydrogel mimicking hepatic biomechanical cues. In 2011 she receive her PhD with the thesis entitled “Development of a modular microfabrication system to engineer complex tissues” at the University of Rome. In 2012 Annalisa joined the Institute of Clinical Physiology of the Italian National Research Council as post-doctoral research fellow, working on a FP7 project aiming at the characterisation of materials to engineer soft tissues. In 2014 Annalisa joined the University of Manchester as research associate, being appointed as Lecturer in Pharmaceutics with the School of Pharmacy (University of Manchester) few months after.

Memberships of committees and professional bodies

Royal Society of Chemistry, Fellow

Royal Microscopical Society, Member

Tissue Engineering and Regenerative Medicine International Society, Member

External positions

Research Fellow, Institute of Clinical Physiology

Feb 2013Jun 2014

Lecturer in Biomaterials, University of Cagliari

Nov 2012Dec 2013

Research Associate, Universita di Pisa

Oct 2010Jan 2013

Areas of expertise

Research Networks and Beacons

Keywords

  • nano medicine, drug delivery, biomaterials, Tissue engineering, Regenerative Medicine, 3D in vitro models, hydrogel, stiffness, microencapsulation

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