I have established expertise in manufacturing of nano- and micro-technologies for biomedical applications, design and modification of biomaterials, optimisation of physico-chemical and mechanical properties of biomaterials and formulation of nanoparticles.
My research group, the BioEngineered Systems research group, is highly multidisciplinary and focuses on two research interests:
1) Formulate nano- and micro-systems encapsualting therapeutics for advanced drug delivery. Current research projects focus on: nanoparticles for targeted delivery to cancer cells (e.g. receptor mediated), nanoparticles for controlled drug release.
2) Design of 3D in vitro systems replicating physiological and pathological charcteristics. Current research projects focus on: biomaterials with controlled stiffness and composition to study cell-material interaction in cancer progression, 3D systems for the release of distinctive biochemicals e.g. protein.
The ultimate aim is to develop high-throughput in vitro systems able to replicate distinctive properties of tissues to better test drug delivery and therapeutic effects.
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Annalisa started her research for the design and manufacturing of in vitro models for tissue engineering and regenerative medicine since her bachelor thesis in Bioengineering at the University of Pisa, developing a microfluidic bioreactor for toxicology drug screening and designing 3D cell laden hydrogel mimicking hepatic biomechanical cues. In 2011 she receive her PhD with the thesis entitled “Development of a modular microfabrication system to engineer complex tissues” at the University of Rome. In 2012 Annalisa joined the Institute of Clinical Physiology of the Italian National Research Council as post-doctoral research fellow, working on a FP7 project aiming at the characterisation of materials to engineer soft tissues. In 2014 Annalisa joined the University of Manchester as research associate, being appointed as Lecturer in Pharmaceutics with the School of Pharmacy (University of Manchester) few months after.
Memberships of committees and professional bodies
Royal Society of Chemistry, Fellow
Royal Microscopical Society, Member
Tissue Engineering and Regenerative Medicine International Society, Member
Research Fellow, Institute of Clinical PhysiologyFeb 2013
→ Jun 2014
Lecturer in Biomaterials, University of CagliariNov 2012
→ Dec 2013
Research Associate, Universita di PisaOct 2010
→ Jan 2013