Adam Greenstein is a clinician scientist at the University of Manchester. At Manchester University Hospitals Foundation Trust, Adam works as a consultant physician as part of the internationally renowned Hypertension (high blood pressure) service. Adam also works as a consultant geriatrician (Care of the Elderly doctor). His clinical expertise is in diagnosis and management of hypertension, prevention of hypertension induced brain disease (vascular dementia and stroke) and in obesity-related hypertension.
At the University of Manchester and adjacent to his clinical work at the hospital, Adam runs a laboratory based basic sciences research programme investigating the diseases he sees in his day-to-day clinical practice. The laboratory seeks to understand precisely how high blood pressure damages small arteries and how this relates to the development of diseases such as Vascular Dementia or kidney disease. The group is also investigating the commonality of small artery damage shared between Alzheimer's Disease and Vascular Dementia. A second focus of his laboratory is the mechanism by which people develop high blood pressure when they put on weight, a condition called obesity-related hypertension.
Adam has published his work in all of the world's top cardiovascular journals including Circulation, Circulation Research, Hypertension and the Journal of the American College of Cardiology. He also regularly publishes in top ranked science journals such as Proceedings of the National Academy of Sciences (PNAS), The Journal of Clinical Investigation (JCI), Nature Communications and Science Signaling. Adam frequently presents work from his laboratory at international scientific and medical meetings.
Adam's research has been funded by the British Heart Foundation continuously for over 10 years and his work has featured on several promotional campaigns for them (Father's Day, Gifts and Wills - see 'Media'). In 2020, Adam's work on the mechanisms responsible for obesity related hypertension was awarded 'Best Basic Science Paper' by the American Heart Association journal 'Hypertension'.
Dr Greenstein trained in medicine at the University of Manchester, during which he also completed an undergraduate degree in Pharmacology. After completion of junior doctor posts in Yorkshire, he trained in Hypertension at Manchester Royal Infirmary where he continues to work. His PhD investigated the interplay between adipose tissue and small resistance arteries in obesity. This was followed by a BHF Travel Fellowship on Vascular Physiology with Professor Mark Nelson at the University of Vermont. Between 2012 and 2016, he was recipient of a BHF Intermediate Clinical Research Fellowship.