Dr Greenstein is a consultant hypertension physician at Manchester University Foundation Hospital Trust and a Clinical Senior Lecturer in Cardiovascular Sciences at the University of Manchester.
He runs a clinical and laboratory research programme investigating the relationship between hypertension and small artery function. The work builds on discoveries made in 2009 demonstrating that fat surrounding blood vessels secretes hormones which lower blood pressure. However, in obese patients, the secretory profile of the fat changes and loss of these hormones leads to abnormal vascular function and hypertension.
Dr Greenstein trained in medicine at the University of Manchester, during which he also completed an undergraduate degree in Pharmacology. After completion of junior doctor posts in Yorkshire, he trained in Hypertension at Manchester Royal Infirmary where he continues to work. His PhD investigated the interplay between adipose tissue and small resistance arteries in obesity. This was followed by a BHF Travel Fellowship on Vascular Physiology with Professor Mark Nelson at the University of Vermont. Between 2012 and 2016, he was recipient of a BHF Intermediate Clinical Research Fellowship.
Dr Greenstein has published his work in journals such as Circulation, Hypertension, PNAS, Science Signaling and Nature Communications in addition to presenting workshops and new data on the microcirculation at major international conferences. His work is funded in its entirety by the British Heart Foundation. His focus of the lab is on the mechanisms by which hypertension affects small artery function and how this leads to target organ damage such as small vessel disease of the brain (vascular dementia), or heart disease.
Dr Greenstein is patron of the Manchester Medical Students Research Society and supports this activity through the INSPIRE grant programme of the Academy of Medical Sciences.