I study human placental physiology and toxicology. My expertise includes transplacental transfer of solute and water, the transplacental paracellular route and the regulation of fetoplacental vascular tone. I have an interdisciplinary relationship with: (i) mathematicians interested in the study of oxygen transfer across the placenta; (ii) a pharmaclogist on placental-targetted nanoparticle therapies for pregnancy realted diseases; (iii) obstetricians interested in understanding the effect of materna l anti-hypertensive treatments on fetal growth and development; and (iv) an immunologist interested in understanding the effects of carcinogenic pollutants in evoking childhood leukaemia during the in utero period.
I have had industrial funding as a PI on translation driven research investigating the aetiology of compromised fetoplacental blood flow in relation to the fetoplacental endothelium and evaluating the safety of potential therapies for fetal growth restriction and preeclampsia. I am interested in maternal and fetal blood flow; and participating in an international network of placental physiologists, pathologists, biophysicists and mathematical modellers interested in understanding this in relation to normal placental sufficiency and in pathological pregnancies.
I am co-leading an international consortium (PlaNet) of placental physiologists, biophysicists, mathematicians and industrialists to promote human placental models towards regulated testing systems to better understand the reproductive toxicology effects of the human exposome.
Annual hosting of A-level students on work-experince placements.
Associate of Greenhead College "PAWS" program
Speaker to various ProBus (retired business womens meetings)