Senior Lecturer in Ophthalmology with research interests in inherited eye disease and therapies
Director of International PGR
MSc Unit Lead for ‘Disease Modelling and Genome Engineering’
MSc Unit Lead for ‘Genomics of the Eye’.
Portfolio Tutor and PBL Tutor for MBChB Medicine programme.
I gained my PhD at the University of Aberdeen (1990) before completing post-doctoral positions at the University of Edinburgh (1989-1995). I then moved into the field of human genetics when I joined the laboratory of Professor Alan Wright (MRC Human Genetics Unit, Edinburgh) in 1995. There I was part of the team that first published RPGR as the gene mutated in X-linked retinitis pigmentosa RP3 and I went on to make a conditional knockout mouse model for Rpgr and was the first to discover the protein’s centriolar localisation. In 2002 I moved to The University of Manchester where I am now a senior lecturer in ophthalmology. I established and was Directeor of the MSc Genomic Medicine programmes until 2019 and am now the Faculty Director of International PGR. My research interests include correcting the function of mutant proteins associated with human disease using small molecules, and epigenetic modification of gene expression to correct pathogenic mutations.